Evidence map›Paper›PMID 40593012›Full record

ArticleScientific reports2025

Topical application of the HSP90 inhibitor 17-AAG reduces skin inflammation and partially restores microbial balance: implications for atopic dermatitis therapy.

Krzysztof Sitko, Ewa Piotrowska, Magdalena Podlacha, Natalia Zagórska, Michał D Starke, Magdalena Trzeciak, Stefan Tukaj

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Krzysztof SitkoDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.ORCID https://orcid.org/0000-0001-7842-7555
Ewa PiotrowskaDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.ORCID https://orcid.org/0000-0002-8899-2010
Magdalena PodlachaDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.ORCID https://orcid.org/0000-0002-7709-5955
Natalia ZagórskaDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.ORCID https://orcid.org/0009-0009-4554-8612
Michał D StarkeDepartment of Plant Experimental Biology and Biotechnology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.ORCID https://orcid.org/0000-0002-0105-8533
Magdalena TrzeciakDepartment of Dermatology, Venereology and Allergology, University Clinical Center in Gdańsk, Gdańsk, Poland.ORCID https://orcid.org/0000-0002-8206-8441
Stefan TukajDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland. stefan.tukaj@ug.edu.pl.ORCID https://orcid.org/0000-0003-1288-0511

Funding

Polish National Science Centre (NCN) 2020/39/B/NZ6/00357
6 · The paper itself

Abstract

Heat shock proteins belonging to the HSP90 family promote inflammation and are potential therapeutic targets in inflammatory and autoimmune diseases. Here the effects of the HSP90 inhibitor 17-AAG applied topically were evaluated in a DNCB-induced murine model of atopic dermatitis (AD). The use of 17-AAG improved clinical disease activity without causing toxicity in the animals. Topical application of 17-AAG resulted in reduced epidermal hyperplasia, decreased expression of TSLP, IL-5, and IL-6, as well as reduced activation of NF-κB in the skin. In addition, the eosinophil proportion in the blood and eosinophil peroxidase (EPX) activity in the skin were significantly reduced in 17-AAG-treated AD mice. The inhibitory effects of 17-AAG on the production of epidermal alarmins, T-helper cell-associated cytokines, and ROS release were demonstrated in cultures of activated human keratinocytes, CD4

Indexed as

BenzoquinonesDermatitis, AtopicHSP90 Heat-Shock ProteinsLactams, MacrocyclicSkinAdministration, TopicalAnimalsCytokinesDisease Models, AnimalEosinophilsFemaleGastrointestinal MicrobiomeHumansInflammationKeratinocytesMiceBenzoquinonesCytokinesHSP90 Heat-Shock ProteinsLactams, MacrocyclictanespimycinEosinophilesHeat shock proteinsKeratinocytes.MicrobiotaMouse modelStaphylococcus aureus

Identifiers

PMID40593012
PMCPMC12216750

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.