ReviewResults and problems in cell differentiation2025
Acetylation in Cardiac Aging: Molecular Mechanism and Therapeutic Approaches.
Review in Results and problems in cell differentiation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The metabolic-epigenetic landscape of aging: interplay between histone acetylation, lactylation, and glycation.Frontiers in aging · 2026Review
- Mandibular extracellular vesicles mediate morphogenesis and mineralization of tooth germs in miniature swine through the miR-206/HDAC4 signaling axis.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This chapter highlights the hallmarks of cardiac aging, distinguishing characteristics between cardiac aging and cardiac senescence. An overview of the molecular mechanisms underlying cardiac aging, with a particular focus on the role of reversible protein acetylation, emphasizes the role of sirtuins in regulating heart function and structure. The chapter explores how alterations in energy metabolism contribute to heart dysfunction, with a focus on the impact of mitochondrial dysfunction and phenomena of protein acetylation, along with the role of acetylase and deacetylase in an aging heart. Additionally, the chapter discusses the regulation of cardiomyocyte proliferation and the potential for enhancing cardiac regeneration. Finally, therapeutic strategies, including caloric restriction and HDAC inhibitors, microRNAs, stem cells, and other pharmacological agents are examined as potential approaches to slow or reverse the effects of cardiac aging.
Indexed as
Identifiers
40593213What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.