ArticleCommunications medicine2025
Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Exploring gut microbiome alterations and hormonal imbalances in polycystic ovary syndrome: insights from a comparative study.Journal of ovarian research · 2026Article
- Natural Products in the Metabolic and Endocrine Modulation of Polycystic Ovary Syndrome: Current Perspectives.Nutrients · 2026Review
- Investigating the impact of phthalate exposure on endocrine function in women with polycystic ovary syndrome.BMC endocrine disorders · 2026Article
- Choline-Mediated Regulation of Follicular Growth: Interplay Between Steroid Synthesis, Epigenetics, and Oocyte Development.Biology · 2025Review
- Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments.Communications medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolycystic Ovary Syndrome (PCOS) affects up to 10% of women of reproductive age, characterized by hormonal imbalances and metabolic complications. Environmental factors potentially influence the biochemical expression of this condition. This study aims to examine the impact of urban versus rural environments on metabolite profiles in women with PCOS.
methodsThirty women aged between 18 and 40, diagnosed with PCOS according to the Rotterdam 2003 criteria, were recruited from June 2022 to May 2023, 16 from urban settings and 14 from rural settings. Serum samples were analyzed using liquid chromatography-tandem mass spectrometry. Principal component analysis and orthogonal partial least squares discriminant analysis were performed to identify metabolic patterns and differences between the two groups.
resultsThis study reveals significant differences in metabolite profiles between women with PCOS from various environmental backgrounds. Rural participants exhibit higher levels of lipid-related metabolites, especially Palmitone, indicating specific dietary influences. Urban participants show distinct changes in carbohydrate and nucleotide metabolism pathways, likely due to processed food consumption. Multivariate analyses demonstrate a clear separation between the groups, emphasizing the environmental impact on PCOS expression.
conclusionsThis research highlights potential environment-related biomarkers for PCOS, emphasizing the importance of developing tailored treatment strategies considering environmental factors. The distinct metabolic profiles observed between urban and rural women provide new insights into the syndrome's complex mechanisms, indicating that environmental influences play a critical role in its biochemical expression and may affect its clinical manifestations.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.