Evidence map›Paper›PMID 40593512›Full record

ArticleNature communications2025

Brain-wide input-output analysis of tuberal nucleus somatostatin neurons reveals hierarchical circuits for orchestrating feeding behavior.

Esra Senol, Menghan Wang, Yongjuan Xin, Zhuolei Jiao, Hasan Mohammad, Xin Yi Yeo, Tengxiao Si, David M Young, Hua Huang, Yingxue Wang and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Esra Senol *Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.ORCID http://orcid.org/0000-0003-4878-0520
Menghan Wang *Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.
Yongjuan Xin *Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.ORCID http://orcid.org/0000-0003-1716-5728
Zhuolei JiaoInstitute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0009-0002-3506-3493
Hasan MohammadInstitute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.ORCID http://orcid.org/0000-0002-5309-4034
Xin Yi YeoInstitute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.ORCID http://orcid.org/0000-0003-1546-4564
Tengxiao SiState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.
David M YoungDepartment of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Hua HuangDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yingxue WangInstitute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.
Qin LiState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.
Sang Yong JungInstitute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.
Xiaohong XuSchool of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200332, China. xiaohongxu46@gmail.com.
Pei ZhangInstitute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore. zhangpei@hust.edu.cn.ORCID http://orcid.org/0000-0003-0608-5677
Yu FuInstitute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore. fu_yu@imcb.a-star.edu.sg.ORCID http://orcid.org/0000-0002-9226-1982

Funding

Agency for Science, Technology and Research (A*STAR) 1530700142Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development) 2021ZD0203203 and 2021ZD0204400MOH | National Medical Research Council (NMRC) OFIRG20nov-0030National Natural Science Foundation of China (National Science Foundation of China) 31900708
6 · The paper itself

Abstract

Feeding is an innate behavior critical for survival but is also influenced by many non-nutritional factors such as emotion, social context and environmental conditions. Recently, tuberal nucleus somatostatin (

Indexed as

BrainFeeding BehaviorNerve NetNeuronsSomatostatinAgouti-Related ProteinAnimalsMaleMiceMice, Inbred C57BLNeural PathwaysAgouti-Related ProteinSomatostatin

Identifiers

PMID40593512
PMCPMC12216382

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.