Evidence map›Paper›PMID 40593569›Full record

ArticleNature communications2025

Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells.

Yi-Chuan Wang, Ping-Hsun Wu, Wen-Chieh Ting, Yi-Fu Wang, Ming-Han Yang, Tung-Hung Su, Jia-Ying Su, Hsun-I Sun, Wei-Min Huang, Pei-Ling Tsai and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Yi-Chuan WangProgram in Molecular Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID http://orcid.org/0009-0003-3818-6138
Ping-Hsun Wu *Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wen-Chieh Ting *Tai-Chen Stem Cell Therapy Center, National Taiwan University, Taipei, Taiwan.
Yi-Fu Wang *Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Ming-Han Yang *Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0009-0008-2697-7254
Tung-Hung Su *Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jia-Ying Su *Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-5934-5458
Hsun-I SunTai-Chen Stem Cell Therapy Center, National Taiwan University, Taipei, Taiwan.
Wei-Min HuangRetain Biotech, New Taipei City, Taiwan.
Pei-Ling TsaiRetain Biotech, New Taipei City, Taiwan.
Gerlinde WernigDepartment of Pathology, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-5169-8731
Ping-Chih HoDepartment of Oncology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-3078-3774
Limei WangDepartment of Oncology, University of Lausanne, Lausanne, Switzerland.
Chen-Tu WuDepartment of Pathology, National Taiwan University Cancer Center, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Yih-Leong ChangDepartment of Pathology, National Taiwan University Cancer Center, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-5309-0554
Tseng-Cheng ChenDepartment of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Tzu-Ching MengInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Yao-Ming ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-6618-862X
Shih-Lei LaiInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chia-Wei LiInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-2531-2866
Tai-Ming KoInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-7546-5724
Kai-Chien YangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Ya-Jen ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0003-1377-6142
Yijuang ChernInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-5842-5429
Mei-Chuan KuoDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yen-Tsung HuangInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Yi-Shiuan TzengInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Jih-Luh TangTai-Chen Stem Cell Therapy Center, National Taiwan University, Taipei, Taiwan.
Shih-Yu ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. sychen@ibms.sinica.edu.tw.ORCID http://orcid.org/0000-0002-7955-481X

Funding

Academia Sinica AS-CFII-108107Academia Sinica AS-CFII-111-204Academia Sinica AS-CFII-111-212Kaohsiung Medical University Chung-Ho Memorial Hospital (Kaohsiung Medical University Hospital) KMUH110-0M13Kaohsiung Medical University Chung-Ho Memorial Hospital (Kaohsiung Medical University Hospital) KMUH110-0R19Kaohsiung Medical University Chung-Ho Memorial Hospital (Kaohsiung Medical University Hospital) KMUH111-1M09Kaohsiung Medical University Chung-Ho Memorial Hospital (Kaohsiung Medical University Hospital) KMUH111-1R14Kaohsiung Medical University (KMU) NHRIKMU-111-I001-3Kaohsiung Medical University (KMU) NHRIKMU-111-I003Kaohsiung Medical University (KMU) NHRIKMU-111-I003-1Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) MOST 112-2314-B-002-091-MY3
6 · The paper itself

Abstract

In eukaryotic cells, reactive oxygen species (ROS) serve as crucial signaling components. ROS are potentially toxic, so constant adjustments are needed to maintain cellular health. Here we describe a single-cell, mass cytometry-based method that we call signaling network under redox stress profiling (SN-ROP) to monitor dynamic changes in redox-related pathways during redox stress. SN-ROP quantifies ROS transporters, enzymes, oxidative stress products and associated signaling pathways to provide information on cellular redox regulation. Applied to diverse cell types and conditions, SN-ROP reveals unique redox patterns and dynamics including coordinated shifts in CD8

Indexed as

CD8-Positive T-LymphocytesOxidative StressSignal TransductionSingle-Cell AnalysisAnimalsHumansMiceOxidation-ReductionReactive Oxygen SpeciesReactive Oxygen Species

Identifiers

PMID40593569
PMCPMC12215076

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.