Evidence map›Paper›PMID 40593621›Full record

ArticleNature communications2025

HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer's disease.

Byung Jo Choi, Ju Yeon Hong, Min Hee Park, Kang Ho Park, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Kyung Yeol Kim, Sun Ae Lee, Eun Young Lim and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Exosome-mediated siRNA delivery in cancer: Loading strategies, targeting approaches, and therapeutic outcomes.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Byung Jo ChoiKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Ju Yeon HongKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Min Hee ParkKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Kang Ho ParkKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Wan Hui HanKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Hee Ji YoonKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Hye Yoon JungKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Kyung Yeol KimKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Sun Ae LeeKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Eun Young LimKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Jung Woo HurKNU AD Research Institute, Kyungpook National University, Daegu, South Korea.
Im-Sook SongBK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea.
So Yeon JeonCollege of Pharmacy, Dankook University, Cheon-an, South Korea.
Min-Koo ChoiCollege of Pharmacy, Dankook University, Cheon-an, South Korea.
Christina ChristoffersenDepartment of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3751-5203
Hee-Jin KimDepartment of Neurology, College of Medicine, Hanyang University, Seoul, South Korea.ORCID http://orcid.org/0000-0001-7880-690X
Seung Hyun KimDepartment of Neurology, College of Medicine, Hanyang University, Seoul, South Korea.ORCID http://orcid.org/0000-0001-9644-9598
Edward H SchuchmanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jae-Sung BaeKNU AD Research Institute, Kyungpook National University, Daegu, South Korea. jsbae@knu.ac.kr.ORCID http://orcid.org/0000-0002-8270-0072
Hee Kyung JinKNU AD Research Institute, Kyungpook National University, Daegu, South Korea. hkjin@knu.ac.kr.ORCID http://orcid.org/0000-0001-6403-008X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating blood factors are critical for homeostasis of the adult ventricular-subventricular (V-SVZ) and subgranular zones, which contain neural stem cells (NSCs) crucial for sustained neurogenesis. Circulating sphingosine-1-phosphate (S1P) bound to apolipoprotein M (ApoM), a principal component of high-density lipoproteins, is involved in various biological processes, but its role in neurogenic niches is poorly understood. Herein, using Apom

Indexed as

Alzheimer DiseaseApolipoproteins MLateral VentriclesLipoproteins, HDLLysophospholipidsSphingosineAgedAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicApolipoproteins MApoM protein, mouseLipoproteins, HDLLysophospholipidsSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate Receptors

Identifiers

PMID40593621
PMCPMC12216268

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.