ArticleNature communications2025
Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Research Advances and Future Perspectives of Point-of-Care Detection Technologies and Biosensors for Mosquito-Borne Viruses.Biosensors · 2026Review
- Vector competence acrossJournal of virology · 2026Review
- Small RNA genomics of Aedes aegypti mosquitoes discovers infectious viruses that trigger an RNA interference response.Nature communications · 2026Article
- Article
- The dengue virus NS1 protein altersmBio · 2026Article
- Altered histone modifications in Aedes aegypti midguts following Rift Valley fever virus exposure.Scientific reports · 2026Article
- Blood feeding, microbiota, and layered mosquito immunity: from pathway phenotypes to vector competence.Frontiers in immunology · 2026Review
- Characterization of Anopheles gambiae immune cells through genetic and functional immunophenotyping.Nature communications · 2025Article
- A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes.Nature communications · 2025Article
- Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus.Nature communications · 2025Article
- Altered histone modifications inbioRxiv : the preprint server for biology · 2025Article
- Article
- Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal.Cell genomics · 2025Article
- Article
- Influence of blood feeding and infection on arthropod hemocytes.Current opinion in insect science · 2025Review
- A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism.Frontiers in immunology · 2025Article
- Exploring new dimensions of immune cell biology inbioRxiv : the preprint server for biology · 2024Article
- Effect of C-type lectin 16 on dengue virus infection inPNAS nexus · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Mosquito-borne arboviruses cause more than 400 million annual infections, yet despite their public health importance, the mechanisms by which arboviruses infect and disseminate in the mosquito host are not well understood. Here, we provide evidence that dengue virus and Zika virus actively infect Aedes aegypti hemocytes and demonstrate, through phagocyte depletion, that hemocytes facilitate virus infection to peripheral tissues including the ovaries and salivary glands. Adoptive transfer experiments further reveal that virus-infected hemocytes efficiently confer virus infection to naïve recipient mosquitoes. Together, these data support a model of arbovirus dissemination where infected hemocytes enhance virus infection of mosquito tissues required for transmission, which parallels vertebrate systems where immune cell populations promote virus dissemination. This study significantly advances our understanding of virus infection dynamics in the mosquito host and highlights potential conserved roles of immune cells in arbovirus infection across vertebrate and invertebrate systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.