Evidence map›Paper›PMID 40593679›Full record

ArticleNature communications2025

Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice.

Szilvia Vas, Paul G Morris, Zulfiye Gul, Miguel Ruiz-Cruz, Su Young Han, Allan E Herbison

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Szilvia VasDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Paul G MorrisDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-4554-2132
Zulfiye GulDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Miguel Ruiz-CruzDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Su Young HanDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Allan E HerbisonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. aeh36@cam.ac.uk.ORCID http://orcid.org/0000-0002-9615-3022

Funding

Wellcome TrustWellcome Trust (Wellcome) 212242/Z/18/Z
6 · The paper itself

Abstract

Brainstem noradrenaline (NA) neurons modulate the activity of many neural networks including those responsible for the control of fertility. Using brain slice electrophysiology, we demonstrate that the arcuate nucleus kisspeptin (ARN

Indexed as

Adrenergic NeuronsBrain StemGonadotropin-Releasing HormoneKisspeptinsNeuronsNorepinephrineAnimalsArcuate Nucleus of HypothalamusFemaleLocus CoeruleusMaleMiceMice, Inbred C57BLGonadotropin-Releasing HormoneKisspeptinsNorepinephrine

Identifiers

PMID40593679
PMCPMC12215617

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.