ArticleScientific reports2025
Evaluation of anti-cancer and Immunomodulatory effects of Globe Thistle (Echinops Shakrokii S.A. Ahmad) extracts: an in vitro and in vivo study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Ellagic Acid and Metformin: In Vitro Synergy and Enhanced Cisplatin Efficacy In Vivo in Resistant Breast Cancer.Nutrients · 2026Article
- Mechanisms and Therapeutic Targets of Botanicals Derived from Asteraceae Plant Species.Pharmaceutics · 2026Review
- Solvent-Based Extraction Recovers Phytochemicals from Medicinal Plants Demonstrating Anticancer and Chemopreventive Potential: A Review.Molecules (Basel, Switzerland) · 2026Review
- First comprehensive GC-MS profile of Echinops erinaceus with antimicrobial and cytotoxic activities and in-silico model.Scientific reports · 2026Article
- A repurposing Dapagliflozin via polymeric nanogels for colorectal cancer therapy.Scientific reports · 2026Article
- Targeting cancer hallmarks using resveratrol: isolation, formulation, and mechanisms of action.Frontiers in nutrition · 2026Review
- Piperine as a modulator of cancer hallmarks: mechanistic insights and therapeutic potential.Frontiers in oncology · 2026Review
- Bee venom and thymoquinone combination inhibits cancer cells by inducing cell cycle arrest and apoptosis.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Echinops L. is recognized for its anticancer and immunomodulatory properties. This study is the first to investigate the potential anticancer and immunomodulatory effects of Echinops shakrokii S.A. Ahmad, collected from Kurdistan, Iraq, employing both in vitro and in vivo methods. Solvent extracts (ethyl acetate, aqueous methanol, and aqueous) from the aerial parts of the plant were prepared via maceration and Soxhlet extraction. The MTT assay assessed antiproliferative efficacy against the MCF-7, MDA-MB-231, EMT6/P, HeLa, T47-D, Caco-2, and VERO cell lines, with results compared to doxorubicin as a positive control. Apoptosis induction was evaluated using an ELISA kit. Immune system activation was assessed through assays of lymphocyte proliferation and macrophages' pinocytic and phagocytic activities. LC-MS identified phytochemicals in the three extracts. EMT6/P cancer cells were injected intraperitoneally into Balb/c mice to investigate the anticancer activity of the aqueous methanol extract. Liver and kidney toxicities were also evaluated. Due to the presence of various phytochemical components, including flavonoids, phenolic compounds, alkaloids, and terpenoids, the ethyl acetate and aqueous methanol extracts exhibited significant antiproliferative effects. The aqueous methanol extract demonstrated the highest potency against the T47D cell line (IC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.