Evidence map›Paper›PMID 40594501›Full record

ArticleScientific reports2025

Transcriptomic and network toxicology approaches reveal potential mechanisms of DEHP induced intrahepatic cholestasis during pregnancy.

Lun Zhang, Qianqian Huang, Yun Yu, Yue Jiang, Mengzhen Hou, Wenkang Tao, Cheng Zhang, Jianqing Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lun Zhang *Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230012, China.
Qianqian Huang *Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230012, China.
Yun Yu *Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230012, China.
Yue JiangDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230012, China.
Mengzhen HouDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230012, China.
Wenkang TaoDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230012, China.
Cheng ZhangDepartment of Toxicology, School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230032, China. zhangchengdev@126.com.
Jianqing WangDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230012, China. jianqingwang81@126.com.

Funding

Anhui public health clinical center, the first affiliated hospital of Anhui medical university north area scientific research cultivation fund project 2023YKJ06Anhui public health clinical center, the first affiliated hospital of Anhui medical university north area scientific research cultivation fund project 2023YKJ11Anhui public health clinical center, the first affiliated hospital of Anhui medical university north area scientific research cultivation fund project 2023YKJ14Health Research Project of Anhui Province AHWJ2023A20294Scientific Research Fund of Anhui Medical University 2023xkj043
6 · The paper itself

Abstract

The objective of this study was to investigate the hepatotoxic effects and molecular mechanisms underlying di(2-ethylhexyl) phthalate (DEHP)-induced intrahepatic cholestasis of pregnancy (ICP) through a network toxicology approach. Utilizing liver transcriptomics in conjunction with the GeneCards, DisGeNET, and OMIM databases, we identified 151 potential targets associated with DEHP-induced ICP. Subsequent analyses employing STRING and cytoscape software revealed five core targets: EGFR, STAT3, JUN, FOS, and HSP90AA1. Functional enrichment analysis via gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathways indicated significant involvement in cholesterol synthesis, bile salt secretion, and the MAPK signaling pathway. Molecular docking studies conducted using AutoDock demonstrated strong binding affinities between DEHP and these core targets. In conclusion, this study offers novel insights into the molecular mechanisms of DEHP-induced hepatotoxicity during pregnancy while providing a systematic framework for assessing risks associated with DEHP exposure; thus contributing to the prevention and treatment of ICP.

Indexed as

Cholestasis, IntrahepaticDiethylhexyl PhthalatePregnancy ComplicationsTranscriptomeFemaleGene Expression ProfilingGene Regulatory NetworksHumansLiverMolecular Docking SimulationPregnancyDiethylhexyl PhthalateDi-2-ethylhexyl phthalateHepatotoxicityIntrahepatic cholestasis of pregnancyNetwork toxicologyTranscriptomics

Identifiers

PMID40594501
PMCPMC12214484

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.