Evidence map›Paper›PMID 40594763›Full record

ArticleScientific reports2025

Identification of key genes associated with cellular aging and mitochondria in acute myocardial infarction.

Dehong Chen, Lingling Yao, Ke Mo, Linan Li, Zhiheng Liu, Zhengyuan Xia, Hanlin Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dehong Chen *Department of Urology, Shenzhen Guangming District People's Hospital, Shenzhen, 518106, Guangdong, China.
Lingling Yao *Department of Anesthesiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Ke MoDepartment of Anesthesiology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, Guangdong, China.
Linan LiDepartment of Pain, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, China.
Zhiheng LiuDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, No. 3002 Sungang West Road, Futian District, Shenzhen, 518035, Guangdong, China.
Zhengyuan XiaDepartment of Anesthesiology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 16 Tongbai North Road, Zhongyuan District, Zhengzhou, 450007, Henan , China.
Hanlin DingDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, No. 3002 Sungang West Road, Futian District, Shenzhen, 518035, Guangdong, China. dinghanlin33@163.com.

Funding

Sanming Project of Medicine in Shenzhen SZSM20221107Science,Technology & Innovation Project of Xiongan New Area 2023XAGG0070
6 · The paper itself

Abstract

Acute myocardial infarction (AMI) poses a significant global mortality burden. Utilizing bio informatics, this study explored cellular aging-related genes (CARGs) and mitochondrial-related genes (MRGs). in AMI Public AMI datasets were analyzed using differential expression and weighted gene co-expression network analysis (WGCNA) to identify 1,373 differentially expressed genes (DEGs), of which 643 were upregulated and 730 downregulated. A turquoise module related to cellular aging was identified by gene set variation analysis (WGCNA). Venn analysis revealed 37 candidate genes intersecting DEGs, key module genes, and MRGs. Machine learning, receiver operating characteristic (ROC) analysis, and reverse transcription quantitative polymerase chain reaction (RT-qPCR) validated Isopentenyl-diphosphate delta-isomerase 1 (IDI1) and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) as key AMI genes. A comprehensive lncRNA-miRNA-mRNA network was constructed, and Cyclosporine showed strong binding affinities with IDI1 (-6.2 kcal/mol) and PMAIP1 (-4.8 kcal/mol), indicating therapeutic potential. This study may provide insights into AMI pathogenesis and highlight potential drug targets for further investigation.

Indexed as

Cellular SenescenceMitochondriaMyocardial InfarctionGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansMicroRNAsRNA, Long NoncodingRNA, MessengerMicroRNAsRNA, Long NoncodingRNA, MessengerAcute myocardial infarctionCellular agingKey genesMitochondrial function

Identifiers

PMID40594763
PMCPMC12216652

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.