ArticleScientific reports2025
Alterations in static and dynamic functional network connectivity in subcortical vascular cognitive impairment.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dissociable, species-specific impact of Aβ on static and dynamic functional connectomes.bioRxiv : the preprint server for biology · 2026Article
- Article
- Associations Between Obstructive Sleep Apnea, Macro-Scale Glymphatic Coupling, and Episodic Memory Impairment in Middle-Aged and Older Adults.Nature and science of sleep · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The current study integrated static (sFNC) and dynamic (dFNC) functional network connectivity to investigate the neurobiological mechanisms underlying alterations in static and dynamic functional network connectivity in subcortical vascular cognitive impairment (SVCI). We recruited 80 patients with SVCI (39 males, 41 females) and 83 healthy controls (32 males, 51 females). Clinical and imaging data, including clinical history, neuropsychological assessments, and Magnetic Resonance Imaging (MRI) scans, were collected. We extracted network independent components for sFNC and dFNC using independent component analysis with resting-state functional MRI data. Firstly, changes in sFNC in SVCI were comparatively analyzed. Subsequently, dynamic connectivity was examined using the sliding time window technique and cluster analysis to assess brain functional activity states and temporal properties. Differences in dFNC temporal properties (fractional occupancy, mean dwell time, and number of transitions) and functional connectivity across different time domains between groups were assessed with two sample t-tests. Spearman correlation analyses were performed to explore relationships between sFNC and dFNC changes and cognitive function. In the sFNC analysis, the SVCI group showed significantly decreased interactions between the sensorimotor network and lateral visual network, which was negatively associated with executive function (r = - 0.248, p = 0.027). In the dFNC analysis, brain functional activity was grouped into four highly structured functional connection states. The results revealed one connected state dominated by an increased connectivity pattern, two moderately connected states primarily characterized by increased connectivity with moderate decreases, and one weakly connected state exhibiting a modular connectivity pattern. These findings illustrate the progression in SVCI from connectivity disruption to compensation, eventually leading to a diminished compensatory response. Fractional occupancy and mean dwell time of states were correlated with cognitive function (all p < 0.05). SVCI patients exhibit impairments in both sFNC and dFNC, linked to cognitive decline. Connectivity dynamics reflect the brain's adaptive capacity in response to cognitive impairment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.