Evidence map›Paper›PMID 40595080›Full record

ArticleScientific reports2025

Lablab purpureus phytochemicals demonstrate potential anticancer activity as evidenced through experimental and computational analysis.

Smitha S Bhat, Sushma Jahagirdar, Chandan Dharmashekar, Chompunut Lumsangkul, Sarana Rose Sommano, Sheikh F Ahmad, Haneen A Al-Mazroua, Iman Azimi, Chandan Shivamallu, Shashanka K Prasad

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Smitha S BhatDepartment of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570015, India.
Sushma JahagirdarDepartment of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570015, India.
Chandan DharmashekarDepartment of Microbiology, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570015, India.
Chompunut LumsangkulDepartment of Animal Science, National Chung Hsing University, Taichung City, 40227, Taiwan.
Sarana Rose SommanoPlant Bioactive Compound Laboratory, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50100, Thailand.
Sheikh F AhmadDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Haneen A Al-MazrouaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Iman AzimiDepartment of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3168, Australia.
Chandan ShivamalluDepartment of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570015, India.
Shashanka K PrasadDepartment of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570015, India. shashankaprasad@jssuni.edu.in.

Funding

Ongoing Research Funding Program, King Saud University, Riyadh, Saudi Arabia ORF-2025-709
6 · The paper itself

Abstract

Lablab purpureus, a seasonal delicacy in southern India, has been employed in traditional medicinal practices to treat various ailments due to its rich phytochemical content. In this study, the crude methanolic extract of L. purpureus seeds exhibited potent antioxidant, anti-inflammatory, and cytotoxic activities. Antioxidant activity was demonstrated using the DPPH, hydroxyl radical scavenging, ferric oxide reducing and ABTS radical reducing assays, while anti-inflammatory activity was demonstrated using the RBC membrane stabilization, and protein denaturation assays. LPM exhibited significant in vitro cytotoxicity towards MCF-7 and A549 cell lines, causing apoptosis and cell cycle arrests at the S and G

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicPhytochemicalsPlant ExtractsA549 CellsAntioxidantsApoptosisCell Line, TumorHEK293 CellsHumansMCF-7 CellsMolecular Docking SimulationAntineoplastic AgentsAntineoplastic Agents, PhytogenicAntioxidantsPhytochemicalsPlant ExtractsAnti-breast cancerAnti-lung cancerApoptosisLablab purpureusPhytochemicals

Identifiers

PMID40595080
PMCPMC12215784

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.