ArticleScientific reports2025
Family history of non-communicable diseases and the risk of cardiovascular-kidney-metabolic syndrome.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Cardiovascular-Kidney-Metabolic (CKM) Syndrome Staging and Relevance to Precision Nutrition.Nutrients · 2026Review
- Review
- The association between family history of hypertension and diabetic kidney disease in patients with diabetes: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Muscle Mass Mediates the Effect of Physical Activity and Sedentary Behavior on Metabolic Syndrome, with Differences by Gender.Healthcare (Basel, Switzerland) · 2025Article
- Contemporary and Emerging Therapeutics in Cardiovascular-Kidney-Metabolic (CKM) Syndrome: In Memory of Professor Akira Endo.Biomedicines · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cardiovascular-kidney-metabolic (CKM)-related diseases are known to be influenced by family history; however, few studies have analyzed associations between them. Thus, this study aims to analyze associations between family history of non-communicable diseases with CKM-related diseases and CKM stages. This study utilized data from the Korea National Health and Nutrition Examination Survey to calculate the weighted prevalence and 95% confidence intervals (CI) of CKM syndrome and CKM-related diseases based on family history of non-communicable diseases including hypertension, diabetes, hyperlipidemia, ischemic heart disease, and stroke. Adjusted odds ratios() with 95% CI were calculated using multivariable logistic regression and partial proportional odds models. CKM syndrome was classified according to the criteria established by the American Heart Association (early-advanced stage, 0-4). This study analyzed family history, prevalence rates of CKM-related diseases, and CKM syndrome stages in 57,340 participants. The results indicated higher prevalence rates for individuals with a family history of CKM-related diseases. Furthermore, individuals with such a history were at greater risk of being classified into more advanced stages of CKM syndrome compared to those without. In particular, when focusing on the most advanced stage (stage ≥ 4) of CKM syndrome, a family history of hypertension increased the risk by 43% (95% CI, 32-54), diabetes by 54% (41-67), hyperlipidemia by 97% (41-67), ischemic heart disease by 147% (123-173), and stroke by 106% (90-124). The family history of CKM-related diseases may increase the prevalence of these diseases and influence CKM syndrome progression stages. These findings suggest implementing early diagnosis and management programs that take family history into account.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.