ArticleEye (London, England)2025
Wide-field OCTA quantified peripheral nonperfusion areas predict the risk of subclinical neovascularization.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- The CAPA framework: a conceptual model integrating corrective and preventive strategies for retinal ischemia and neovascularization.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Tubercular retinal vasculitis in widefield optical coherence tomography angiography.American journal of ophthalmology case reports · 2026Article
- Elevated Retinal Neovascularization on Widefield Optical Coherence Tomography Angiography Predicts Complications in High-Risk Proliferative Diabetic Retinopathy.American journal of ophthalmology · 2026Article
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9 authors.
Funding
Abstract
purposeTo demonstrate the capabilities of single-shot widefield swept-source OCT angiography (SS-OCTA) in detecting subclinical retinal neovascularization (RNV), quantifying nonperfusion areas (NPAs), and exploring the relations between NPAs and subclinical RNV in eyes graded as nonproliferative diabetic retinopathy (NPDR).
methodsEyes clinically graded as moderate to severe NPDR underwent SS-OCTA imaging. Expert graders identified subclinical RNV, defined as vessels with a flow signal above the internal limiting membrane on OCTA that are not visible on dilated fundus examination. This identification was based on a combination of en face OCT, en face OCTA, and cross-sectional OCTA overlaid on OCT. NPA index was calculated as a percentage of automatically quantified NPA over the area in the posterior pole, the mid-periphery, and the total imaged area.
resultsTotally 37 eyes, including 21 had severe NPDR and 16 had moderate NPDR. Subclinical RNV was present in 14 eyes (37.8%). The eyes with RNV had significantly higher mid-peripheral and total NPA indices but not in the posterior region (mid-peripheral NPA: 31.97% ± 7.02% vs. 24.80% ± 6.60%, p = 0.041; total NPA: 27.96% ± 6.36% vs. 21.61% ± 5.65%, p = 0.046; all values are reported as mean ± standard deviation). The total NPA index showed the highest diagnostic accuracy for subclinical RNV detection (AUC: 0.761; 95% CI, 0.592-929, with a sensitivity of 64.3% and a specificity of 87% at a cutoff value of 28.84%).
conclusionWidefield SS-OCTA can detect subclinical RNV. The eyes with higher mid-peripheral NPA indices are more likely to have subclinical RNV, indicating that the NPA index may be a useful biomarker for identifying eyes at risk of RNV.
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