Evidence map›Paper›PMID 40595452›Full record

ReviewCell death discovery2025

The biogenesis and biological roles of migrasomes in human diseases.

Yifan Zhang, Wei Chen, Jiageng Zhu, Luwei Xu

Abstract readReview
In one paragraph

Review in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yifan Zhang *Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Wei Chen *Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Jiageng ZhuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China. zhujg72@163.com.
Luwei XuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China. xuluwei1980@126.com.ORCID http://orcid.org/0000-0002-6838-5563

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migrasomes are recently identified extracellular vesicles that are specifically generated by migrating cells. These pomegranate-like, membrane-bound organelles are released at the trailing edge during cell migration and play crucial roles in cell-to-cell communication, intercellular signaling, and tissue remodeling. Migrasomes selectively package various molecular components, including proteins, lipids, and RNA, facilitating a unique form of cellular communication known as migracytosis. They are involved in numerous physiological and pathological processes, including immune responses, cancer metastasis, tissue repair, and embryonic development. In this review, we provide an in-depth analysis of the biogenesis, structural features, and molecular composition of migrasomes. We further explore the emerging roles of migrasomes in disease pathogenesis, particularly their potential in cancer, neurodegenerative diseases, and immune modulation. Overall, this review aims to offer comprehensive insights into the latest research on migrasomes, while addressing the challenges in their study and potential avenues for future clinical implementation.

Identifiers

PMID40595452
PMCPMC12219052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.