SynthesisScientific reports2025
The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-nutritive sweeteners (NNS) have been suggested as a viable solution to reduce sugar consumption. However, conflicting and uncertain evidence regarding their impact on lipid profile exists. This meta-analysis assesses the effects of different types of NNS on lipid profile markers. PubMed, Web of Science ISI, Scopus, and Google Scholar were searched for relevant articles up to September 2024. The Cochrane Collaboration tool was used for the quality assessment, and the evidence's trustworthiness was assessed using the Grading of Assessment, Development, and Evaluation of Recommendations (GRADE). A total of 28 articles revealed that NNS might not have a significant effect on serum triglycerides (Weighted mean difference (WMD): -2.66, 95% confidence interval (CI): -6.29, 0.98 mg/dL, n = 2209, level of confidence: low), total cholesterol (WMD: -0.44, 95% CI: -2.96, 2.08 mg/dl, n = 2047, level of confidence: low), high-density lipoprotein cholesterol (WMD: 0.03, 95% CI: -0.68, 0.74 mg/dl, n = 2097, level of confidence: low), low-density lipoprotein cholesterol (WMD: 0.51, 95% CI: -1.57, 2.59 mg/dl, n = 1777, level of confidence: low) and very low-density lipoprotein (WMD: 2.20, 95% CI: -2.66, 7.06 mg/dl, n = 154, level of confidence: very low). It is demonstrated that NNS might not affect serum lipid profile.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.