ArticleNPJ Parkinson's disease2025
Impact of motor symptom asymmetry on non-motor outcomes in Parkinson's disease: a systematic review.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Association of Reproductive Factors and Postmenopausal Sex Hormones With Cognitive Impairment in Postmenopausal Women With Parkinson's Disease.CNS neuroscience & therapeutics · 2026Article
- Time-Varying Effective Network of Rehabilitation in Parkinson's Disease With Disease Laterality: A TMS-EEG Study.CNS neuroscience & therapeutics · 2026Article
- Differences in Spatial Cognition and Motor-Cognitive Integration by Side of Onset in People with Parkinson's Disease.Brain sciences · 2026Article
- Age, emotional burden and deep brain stimulation electrode location shape Parkinson's disease quality of life.NPJ digital medicine · 2026Article
- Is motor asymmetry a predictor of non-motor outcomes in Parkinson's disease?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Potential Effects of Music on Non-Motor Symptoms in Parkinson's Disease: Translating Mechanisms to Therapy.Neurology international · 2026Review
- The Impact of Motor Symptom Asymmetry on the Relationship Between Non-Motor Manifestations and Neurometabolic Profiles in Parkinson's Disease.International journal of molecular sciences · 2026Article
- Rigorous Validation of Paw Preference Using Three Complementary Behavioral Assays in Sprague Dawley Rats.bioRxiv : the preprint server for biology · 2026Article
- Development and Validation of a Machine Learning Model for Predicting Osteoporosis in Patients with Parkinson's Disease.Neuropsychiatric disease and treatment · 2026Article
- Mapping motor cortex "hand knob" metrics to symptom hemidominance in Parkinson's disease: from width comparison to machine learning.Brain & spine · 2026Article
- Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson's disease.npj women's health · 2026Article
- Insole-Derived Plantar Pressure Variability Reveals Dual-Task Gait Differences in Early-Stage Parkinson's Disease.IEEE journal of translational engineering in health and medicine · 2026Article
- Editorial: Advancing personalized diagnosis and treatment in Parkinson's disease: integrating biomarkers, neuroimaging, and artificial intelligence.Frontiers in neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) presents with diverse symptoms, partly influenced by motor symptom asymmetry, which reflects hemispheric brain specialization. This systematic review of 80 studies explored how lateralized motor symptoms affect non-motor outcomes in PD, including cognition, emotion, and psychiatric health. Patients with right-sided motor symptoms (left-hemisphere pathology) show more global cognitive decline and higher dementia risk, while those with left-sided symptoms (right-hemisphere pathology) more often experience psychiatric issues like depression, anxiety, and impaired emotional recognition. Visuospatial deficits were consistently linked to left-sided symptoms, aligning with right-hemisphere dysfunction. Although findings vary across studies, this pattern suggests the relevance of brain lateralization in non-motor symptom assessment. Motor asymmetry may also affect treatment responses, such as deep brain stimulation outcomes. However, inconsistencies in study methods-definitions of asymmetry, motor subtypes, and comorbidities-limit meta-analytic conclusions. Overall, incorporating motor symptom asymmetry into PD diagnosis and treatment could enhance personalized care, warranting more standardized future research.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.