ArticleScientific reports2025
Detecting a potential causal relationship between plasma metabolites and myocardial infarction using bidirectional and two-step Mendelian randomization.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
Some studies have shown that plasma metabolites may be associated with myocardial infarction (MI); however, the causal relationship between plasma metabolites and MI, as well as the potential mediating role of immune cells, remains unclear. This Mendelian randomisation (MR) study utilised large-scale genome-wide association study (GWAS) summary data encompassing 1400 plasma metabolites (n = 8299), 731 immune cell traits from the GWAS Catalog consortium (n = 3757), and MI cases and controls from the FinnGen consortium (cases: n = 26,060; controls: n = 343,079). Using bidirectional MR analysis, we assessed the causal links between plasma metabolites and MI, and between immune cells and MI, excluding reverse causality. Five MR methods were applied, with inverse variance weighting used as the primary analytical approach. In addition, we conducted two-step MR to identify potential immune cell mediators. We identified 44 positive and 33 negative causal associations between genetic liability to plasma metabolites and MI. Of these, only the association between 3β-hydroxy-5-cholestenoate (OR = 0.909; 95% CI 0.871-0.950; P = 1.84 × 10
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