Evidence map›Paper›PMID 40596364›Full record

ArticleScientific reports2025

Camellia sinensis powder rich in epicatechin and polyphenols attenuates isoprenaline induced cardiac injury by activating the Nrf2 HO1 antioxidant pathway in rats.

Mirza Alimullah, Ishrat Jahan, Md Mizanur Rahman, Ferdous Khan, Khondoker Shahin Ahmed, Md Hemayet Hossain, Hesamoddin Arabnozari, Md Ashraful Alam, Satyajit D Sarker, Lutfun Nahar and 1 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Mirza AlimullahDepartment of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Ishrat JahanDepartment of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Md Mizanur RahmanDepartment of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Ferdous KhanDepartment of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Khondoker Shahin AhmedBCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
Md Hemayet HossainBCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
Hesamoddin ArabnozariMedicinal Plants Research Centre, Institute of Herbal Medicines and Metabolic Disorders, Mazandaran University of Medical Sciences, Sari, Iran. hesamarabnozari@yahoo.com.
Md Ashraful AlamDepartment of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Satyajit D SarkerCentre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK.
Lutfun NaharLaboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Šlechtitelů 27, 78371, Olomouc, Czech Republic. profnahar@outlook.com.
Nusrat SubhanDepartment of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction is a leading cause of death and morbidity in individuals with cardiovascular diseases. Natural antioxidants, such as those found in green tea leaves, are beneficial in preventing these diseases. This study evaluated the protective effects of green tea leaves powder against isoprenaline (ISO)-induced myocardial infarction in rats. Four groups of male Long Evans rats were used: Control, Control + green tea leaves powder, ISO, and ISO + green tea leaves powder. Organ and blood plasma samples were collected to measure oxidative stress biomarkers, biochemical parameters, and gene expressions. Furthermore, tissue sections were prepared and stained histologically. ISO-induced rats showed decreased cellular antioxidants (catalase activity and glutathione concentration) and elevated oxidative stress markers. Notable inflammatory cell infiltration and fibrosis were observed in the heart and kidneys of ISO-induced rats. Supplementation with green tea leaves powder significantly restored catalase activity and glutathione concentration (p < 0.05) in plasma and tissues. It also considerably reduced lipid peroxidation, nitric oxide, and advanced oxidation protein products (p < 0.05) in ISO-administered rats. Furthermore, green tea leaves powder supplementation halted inflammatory gene expression (p < 0.05), restored antioxidant genes (p < 0.05) such as Nrf-2-HO-1, and prevented cardiac fibrosis in ISO-administered rats. Green tea leaves powder supplementation may reduce oxidative stress, inflammation, and fibrosis in ISO-administered rats, potentially through the Nrf-2-HO-1-mediated restoration of antioxidant enzymes and prevention of heart inflammation.

Indexed as

AntioxidantsCamellia sinensisCatechinHeart InjuriesMyocardial InfarctionNF-E2-Related Factor 2PolyphenolsAnimalsHeme Oxygenase (Decyclizing)IsoproterenolMaleMyocardiumOxidative StressPlant ExtractsPowdersRatsAntioxidantsCatechinHeme Oxygenase (Decyclizing)Hmox1 protein, ratIsoproterenolNfe2l2 protein, ratNF-E2-Related Factor 2Plant ExtractsPolyphenolsPowdersCamellia sinensisFibrosisInflammationIsoprenalineMyocardial infarction

Identifiers

PMID40596364
PMCPMC12214831

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.