Evidence map›Paper›PMID 40596433›Full record

ArticleScientific reports2025

MIP-3α-antigen fusion DNA vaccine enhances sex differences in tuberculosis model and alters dendritic cell activity early post vaccination.

James T Gordy, Rowan E Bates, Elizabeth Glass, Jacob Meza, Yangchen Li, Courtney Schill, Alannah D Taylor, Tianyin Wang, Fengyixin Chen, Khaleel Plunkett and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

James T Gordy *Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA. jgordy2@jhu.edu.
Rowan E Bates *Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Elizabeth GlassDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Jacob MezaDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Yangchen LiDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Courtney SchillDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Alannah D TaylorDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Tianyin WangDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Fengyixin ChenDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Khaleel PlunkettDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Styliani KaranikaDepartment of Medicine, Division of Infectious Diseases, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Petros C KarakousisDepartment of Medicine, Division of Infectious Diseases, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Richard B MarkhamDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.

Funding

Sex differences in the impact of frailty on vaccine-induced immune responses in community-dwelling older adultsU54AG062333 · NIA · JOHNS HOPKINS UNIVERSITY · PI KLEIN, SABRA L. · 2018 to 2022
$8.9M
Therapeutic vaccination to augment stringent response-specific T-cell immunity to MTB persistersR01AI148710 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C, MARKHAM, RICHARD B. · 2020 to 2024
$3.8M
Mentoring in Immunometabolic Dysregulation in TB and TB/HIVK24AI143447 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2019 to 2024
$956k
Mechanisms of a therapeutic DNA vaccine targeting Mycobacterium tuberculosis persistersK08AI174959 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Styliani Karanika · 2024 to 2026
$603k
Johns Hopkins Specialized Center for Research Excellence in Sex Differences U54AG062333National Institute of Allergy and Infectious Diseases R01AI148710NIAID NIH HHS K08 AI174959NIAID NIH HHS K24 AI143447NIAID NIH HHS R01 AI148710NIA NIH HHS U54 AG062333
6 · The paper itself

Abstract

Tuberculosis disease (TB) caused by Mycobacterium tuberculosis (Mtb) bacteria remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the Mtb infection. Bacterial persistence during exposure to bactericidal antibiotics is at least partially mediated by the bacterial stringent response enzyme, Rel

Indexed as

Antigens, BacterialChemokine CCL20Dendritic CellsMacrophage Inflammatory ProteinsTuberculosisTuberculosis VaccinesVaccines, DNAAnimalsDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMycobacterium tuberculosisSex FactorsVaccinationAntigens, BacterialChemokine CCL20Macrophage Inflammatory ProteinsTuberculosis VaccinesVaccines, DNAAntigen presenting cell (APC)Dendritic cell (DC)DNA vaccineImmunology sex differencesMIP-3α (CCL20)Mycobacterium tuberculosis (Mtb)

Identifiers

PMID40596433
PMCPMC12218986

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.