Evidence map›Paper›PMID 40596436›Full record

ArticleScientific reports2025

In vitro antiviral activities of thymol and Limonin against influenza a viruses and SARS-CoV-2.

Gomaa Mostafa-Hedeab, Akram Hegazy, Islam Mostafa, Ibrahim H Eissa, Ahmed M Metwaly, Hany Abdelfattah Elhady, Abozer Y Eledrdery, Sager Holyl Alruwaili, Alaa Oqalaa E Alibrahim, Fawaz O Alenazy and 8 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Frontiers in veterinary science · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gomaa Mostafa-Hedeab *Pharmacology Department and Health Research Unit, Medical College, Jouf University, Skaka, 11564, Saudi Arabia. gomaa@ju.edu.sa.
Akram Hegazy *Department of Agricultural Microbiology, Faculty of Agriculture, Cairo University, Giza district 12613, Giza, Egypt.
Islam MostafaDepartment of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Ibrahim H EissaMedicinal Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
Ahmed M MetwalyPharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al- Azhar University, Cairo, 11884, Egypt.
Hany Abdelfattah ElhadySurgery Department, Medical College, Jouf University, Sakaka, 11564, Saudi Arabia.
Abozer Y EledrderyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 11564, Saudi Arabia.
Sager Holyl AlruwailiDepartment of Surgery, Orthopedic Division, College of Medicine, Jouf University, Sakaka, 11564, Saudi Arabia.
Alaa Oqalaa E AlibrahimDepartment of Internal Medicine, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Fawaz O AlenazyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 11564, Saudi Arabia.
Muhannad Faleh Alanazi AlruwailiDepartment of Internal Medicine, Division of Radiology, College of Medicine, Jouf University, Kingdom of Saudi Arabia, 72388, Sakaka, Saudi Arabia.
Thamer Alshami MarghelDepartment of Pediatrics, College of Medicine, Jouf University, Jouf University, Kingdom of Saudi Arabia, 72388, Sakaka, Saudi Arabia.
Muharib AlruwailiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 11564, Saudi Arabia.
Alaaeldin Mohamed SaadDepartment of Zoonoses, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Mahmoud BayoumiDisease Intervention & Prevention (DIP) and Host Pathogen Interactions (HPI), Texas Biomedical Research Institute, Programs, San Antonio, TX, 78227, USA.
Assem Mohamed El-ShazlyDepartment of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Luis Martinez-SobridoDisease Intervention & Prevention (DIP) and Host Pathogen Interactions (HPI), Texas Biomedical Research Institute, Programs, San Antonio, TX, 78227, USA. lmartinez@txbiomed.org.
Ahmed MostafaDisease Intervention & Prevention (DIP) and Host Pathogen Interactions (HPI), Texas Biomedical Research Institute, Programs, San Antonio, TX, 78227, USA. ahmed_elsayed@daad-alumni.de.

Funding

Deanship of Scientific Research at Jouf University DSR2022-RG-0152Texas Biomedical Forum 1520001
6 · The paper itself

Abstract

Emerging and re-emerging respiratory viruses represent a continuing threat to human health. The pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza A viruses (IAVs) are co-circulating, presenting serious threats to public health. Therefore, screening for safe and broad-spectrum antiviral candidates to control such viral infections is prioritized. Herein, this study reports the in vitro antiviral activity of some essential volatile oils (EOs) and volatile oil components including Peppermint oil, Eucalyptus oil, Clove oil, Thymol, Camphor and Limonin against two different IAVs, namely influenza A/H1N1 and A/H5N1 viruses, and SARS-CoV-2 virus. All tested samples were safe in MDCK and Vero E6 cell lines with CC

Indexed as

Antiviral AgentsInfluenza A virusInfluenza A Virus, H1N1 SubtypeSARS-CoV-2ThymolAnimalsChlorocebus aethiopsCOVID-19 Drug TreatmentDogsHumansInfluenza A Virus, H5N1 SubtypeMadin Darby Canine Kidney CellsMolecular Docking SimulationOils, VolatileVero CellsAntiviral AgentsOils, VolatileThymolEssential oilsIAVLimoninRespiratory virusesSARS-CoV-2Thymol

Identifiers

PMID40596436
PMCPMC12217544

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.