Evidence map›Paper›PMID 40596519›Full record

ArticleScientific reports2025

Albuminuria, structural brain findings and Circulating biomarkers of brain injury in older adults.

Jens W Horn, Alison Fohner, Russell Tracy, Hieab H H Adams, Luc Djousse, Solfrid Romundstad, Imre Janszky, W T Longstreth, Kenneth J Mukamal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jens W HornDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. Jens.Horn@ntnu.no.
Alison FohnerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Russell TracyDepartment of Pathology & Laboratory Medicine and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, USA.
Hieab H H AdamsDepartment of Clinical Genetics and Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Luc DjousseDivision of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Solfrid RomundstadDepartment of Internal Medicine, Levanger Hospital, Health Trust Nord-Trøndelag, Levanger, Norway.
Imre JanszkyDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
W T LongstrethDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Kenneth J MukamalDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Funding

Infrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7M
NHLBI NIH HHS R01 HL172803
6 · The paper itself

Abstract

Albuminuria reflects systemic endothelial dysfunction, but its relationships with subclinical brain abnormalities have not been comprehensively catalogued. The Cardiovascular Health Study recruited older adults from four US communities, beginning in 1989-1990. Systematic measurements of albuminuria were performed in 1996-1997; two brain MRIs, in 1992-1994 and 1997-1999; and serum neurofilament light chain (NfL) measurements from 1996-1997 stored samples. We examined the associations of albuminuria with longitudinal progression of white matter hyperintensities (WMH) and ventricular size, incident infarcts, and cross-sectional quantitative brain volumes and circulating biomarkers of neuronal injury (n = 834-1950). Albuminuria was positively associated with ventricular grade worsening (odds ratio per doubling 1.10, 95% confidence interval (CI) 1.01-1.19) and with circulating NfL levels (2% higher per doubling, 95% CI 1-4%), even after adjustment for vascular risk factors. Albuminuria was also associated with worsening of WMH, incident infarcts, and quantitative WMH and hippocampal volumes, but these latter associations appeared to reflect burden of cardiovascular risk factors. Albuminuria is independently associated with worsening ventricular size and circulating NfL, suggesting a specific role of microvascular dysfunction in brain atrophy. It also reflects cardiovascular risk factor burden on markers of vascular brain injury. These results highlight the diverse associations of albuminuria with common brain abnormalities of aging.

Indexed as

AlbuminuriaBiomarkersBrainBrain InjuriesAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleNeurofilament ProteinsRisk FactorsWhite MatterBiomarkersneurofilament protein LNeurofilament ProteinsAlbuminuriaCerebral small vessel diseaseEpidemiologyMagnetic resonance imageNeurofilament light chainRisk factors

Identifiers

PMID40596519
PMCPMC12217312

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.