S100A8 regulated by estrogen improves injured endometrial epithelium reconstruction by promoting tight junction formation and stromal cell transformation.

Xiaodan Li, Fang Jia, Huiwen Bai, Xuejing Chen, Yue Zhang, Ningfang Zhang, Hongxin Yang

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaodan LiCollege of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.

Fang Jia *College of Basic Medicine, Inner Mongolia Medical University, Hohhot, China. jiafang198011@163.com.

Huiwen BaiFirst Clinical Medical College, Inner Mongolia Medical University, Hohhot, China.

Xuejing ChenFirst Clinical Medical College, Inner Mongolia Medical University, Hohhot, China.

Yue ZhangFirst Clinical Medical College, Inner Mongolia Medical University, Hohhot, China.

Ningfang ZhangCollege of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.

Hongxin Yang *College of Basic Medicine, Inner Mongolia Medical University, Hohhot, China. hongxinyang@immu.edu.cn.

Funding

Scientific Research Program in Universities of Inner Mongolia Autonomous Region NJZZ23003The Key Project of Inner Mongolia Medical University YKD2022ZD016The Scientific Research Fund of Inner Mongolia Medical University YKD2023MS039Zhiyuan Telent Project of Inner Mongolia Medical University ZY20241102

6 · The paper itself

Abstract

Estrogen is used for endometrial repair; however, it has limited effectiveness. Cytokine S100A8 expression is affected by estrogen and is involved in regulating the damage repair. We aimed to confirm the effects of S100A8 and explore its mechanisms during the reconstruction of the injured endometrium. We investigated the effects of estrogen on S100A8 expression in healthy endometrium. A rat model of endometrial injury and cultured primary endometrial cells were used to determine the pleiotropic effects of S100A8 on endometrial epithelial repair. Estrogen regulated the recruitment of S100A8-positive immune cells (S100A8-PICs) and the release of S100A8 in the healthy endometrium, but estrogen plays a limited role in regulating seriously injured endometrium via self-S100A8. S100A8 administration to the uterine cavity significantly improved the morphology of injured epithelium; influenced the reverse migration of S100A8-PICs; and promoted epithelial localization of proliferating cells, cell junction formation, and transformation of stromal cells to epithelial cells. S100A8 in the uterine cavity has pleiotropic effects that improve endometrial epithelial reconstruction and can compensate for the deficiency in estrogen repair regulation.

Indexed as

Calgranulin AEndometriumEstrogensStromal CellsTight JunctionsAnimalsCell ProliferationCells, CulturedEpithelial CellsEpitheliumFemaleRatsRats, Sprague-DawleyCalgranulin AEstrogensCell junctionEndometrial injuryEpithelium reconstructionEstrogenS100A8Transformation

Identifiers

PMID40596550

DOI10.1038/s41598-025-08530-0

PMCPMC12219834

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.