ArticleBMC genomics2025
Joint analysis of whole-genome methylation and transcriptome in avian pullorum disease and validation of gene function.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Jejunum FABP6 expression and potential mechanism response to Salmonella Pullorum inoculation revealed by proteomic profiling and RT-PCR in Chinese Taihe black-bone silky fowls.Poultry science · 2026Article
- Scopolamine exerted antidepressant-like behavioral effects via restoring the synaptic plasticity in CRS-treated mice.Metabolic brain disease · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Pullorum disease caused by Salmonella pullorum can negatively affect growth and egg-laying performance, resulting in significant economic losses in poultry farming. In this study, spleen tissues from SP-infected chickens (group P) and SP-uninfected chickens (group N) were analyzed for functional enrichment using whole-genome bisulfite and RNA sequencing. The function of the key gene MSX2 was verified by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay. Results indicated significant changes in the spleen methylation pattern of group P, primarily characterized by hypomethylation in the promoter, intron, and exon regions. Coanalysis identified six genes (MSX2, C21orf62, PGLYRP2, KCNQ3, SEZ6L, and SLC38A11) with significant alterations in differentially methylated regions and differentially expressed genes. MSX2 gene overexpression markedly enhanced the expression and secretion of immune factors [Interferon (IFN)-α, IFN-β, Interleukin (IL)-2, IL-3, and tumor necrosis factor-α] in chicken macrophages, suggesting that MSX2 may play a role in immune regulation in chickens. This study revealed the effects of Salmonella pullorum infection on DNA methylation and gene expression in chicken spleen tissues and screened several potential therapeutic targets, providing new insights and methods for the prevention and control of Pullorum disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.