ArticleBMC infectious diseases2025
Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018-2023).
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The stand-alone Ayurveda treatment for the management of COVID-associated mucormycosis (CAM): a case report.Frontiers in medicine · 2026Article
- Adjuvant Treatment Strategies for Acute Invasive Fungal Rhinosinusitis: An in Vitro Evaluation.Iranian journal of otorhinolaryngology · 2026Article
- Two decades of mucormycosis: molecular epidemiology and antifungal susceptibility trends in Türkiye.Frontiers in cellular and infection microbiology · 2026Article
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17 authors.
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Abstract
purposeThe incidence of Mucormycosis has increased during the last decades globally due to more patients being at risk for these life-threatening infections. Early diagnosis and proper selection of appropriate antifungal therapy are vital in enhancing patient outcomes. Mucorales species present a significant challenge due to their resistance to many drugs, so investigations for new therapies and strategies must be undertaken. This study elucidates the distribution and antifungal susceptibility profiles of Mucorales isolates from Iran over five years.
methodsSpecies identification was performed based on morphological features and Internal Transcribed Spacer (ITS) sequences analysis. Antifungal susceptibility testing for commonly used antifungal agents was conducted following CLSI M38-A3 broth microdilution.
resultsOne hundred eighty-one (116 clinical and 65 environmental) isolates were analyzed. Rhizopus arrhizus (67.9%, n = 123) and Mucor circinelloides (23.2%, n = 42) were the predominant species. The various clinical samples analyzed included sinus biopsies, nasal secretions, orbital tissues, maxilla tissues, throat, and brain tumors.
conclusionThe lowest geometric mean minimum inhibitory concentration values were observed against the clinical and environmental isolates for amphotericin B, posaconazole, and isavuconazole. Understanding Mucorales' distribution and antifungal susceptibility patterns helps clinicians select antifungal therapies. However, further studies are warranted to correlate these findings with clinical outcomes.
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