Evidence map›Paper›PMID 40597964›Full record

ArticleBMC pediatrics2025

24-Week jumping exercise influence on growth speed and GH-IGF-1-IGFBP-3 axis among short-stature children.

Huiming Wang, Xing Wang, Xiang Wang, Xin Xin, Hui Zhang, Shuqi Jia, Wenyuan Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huiming WangDepartment of physical education, Shanghai University of Sport, Shanghai, 200438, China.
Xing WangDepartment of physical education, Shanghai University of Sport, Shanghai, 200438, China. wangxing1933@sus.edu.cn.
Xiang WangDepartment of physical education, East China University of Political Science and Law, Shanghai, 201620, China.
Xin XinDepartment of physical education, Shanghai University of Sport, Shanghai, 200438, China.
Hui ZhangDepartment of Endocrinology, Jiaozuo Second People's Hospital, Jiaozuo, 454150, China.
Shuqi JiaDepartment of physical education, Shanghai University of Sport, Shanghai, 200438, China.
Wenyuan WangWuzhi County Hospital of Traditional Chinese Medicine, Wuzhi County, 454950, China.

Funding

This work was supported by Shanghai Key Lab of Human Performance (Shanghai University of sport) 11DZ2261100
6 · The paper itself

Abstract

objectiveTo explore the effect of jumping exercises on improving short-stature symptoms and changes of serum GH, IGF-1, IGFBP-3, and IGF-1/IGFBP-3 in short-stature patients, so as to provide potential theoretical reference for short-stature treatment.

methodsA non-randomized controlled intervention study was registered on January 8, 2025, with the China Clinical Trial Registry (ChiCTR2500095544). This study was conducted with the recruitment of 15 short-stature children in the same environment (Exercise Experimental Group 1); 20 children with normal development level (Blank Control Group 2); and 27 healthy short-stature children in this area (Short Blank Control Group 3). Children in Group 1 were given exercise intervention for 24 weeks, and those in the other two groups were provided with natural observation for 24 weeks. After the experiment, this study further analyzed the growth values of height, growth hormone (GH), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein 3 (IGF-BP-3) and IGF-1/IGF-BP-3 of the three groups.

resultsAfter 24 weeks of exercise intervention, Group 1 had higher height, serum IGF-1, and the growth value of molar ratio of IGF-1/IGFBP-3 than those of Group 2 and Group 3, with statistically significant difference between Group 1 and Group 3 (all p < 0.05). However, there was no significant difference in serum GH level and its growth value among groups before and after the experiment (p > 0.05),. In addition, the serum IGFBP-3 in Group 1 was lower than that in Group 2 and Group 3 (both p < 0.01).

conclusionThe 24-week jumping exercise intervention can effectively improve the height of short-stature children. It can enhance the function of GH-IGF-1-IGFBP-3 axis through improving serum IGF-3 level and molar ratio of IGF-1/IGFBP-3, while decreasing the level of serum IGFBP-3. Nevertheless, exercise intervention has no effect on morning GH secretion in short-stature children.

Indexed as

Body HeightExerciseExercise TherapyGrowth DisordersHuman Growth HormoneInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IChildFemaleHumansMaleHuman Growth HormoneIGF1 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IExercise to improve heightGHIGF-1IGFBP-3Molar ratio of IGF-1/IGFBP-3Short-stature

Identifiers

PMID40597964
PMCPMC12219976

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.