SynthesisBMC endocrine disorders2025
Evidence on the link between hypothyroidism and non-alcoholic fatty liver disease: an updated systematic review.
Synthesis in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Hypothyroidism and Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms, Clinical Links, and Therapeutic Implications.Current obesity reports · 2026Review
- NAFLD and Hypothyroidism: Deciphering Pivotal Genetic Variants, Cellular Expression Landscapes, and Spatial Architectures.International journal of molecular sciences · 2026Article
- Markers Of Insulin Resistance and Their Clinical Implications In Patients with Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- ECM remodeling in hypothyroidism-associated MAFLD: mechanisms, clinical relevance, and therapeutic targets.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous studies have investigated the relationship between hypothyroidism and non-alcoholic fatty liver disease (NAFLD), while the underlying mechanisms are not well understood. This systematic review evaluated the mentioned relationship among non-diabetic adults.
methodsThis systematic review was written in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar until January 2024. After a critical analysis, 29 observational studies were included in the present systematic review.
resultsThe available observational evidence suggests a potential association between hypothyroidism and NAFLD. Regarding this complex relationship, patients with hypothyroidism may be more likely to develop NAFLD compared to those with normal thyroid function. Several factors are involved in the development of hypothyroidism-induced NAFLD.
conclusionsThyroid hormones regulate energy and metabolism, suggesting their relevance in NAFLD. Increased awareness and optimized strategies are needed for mutual screening and managing thyroid disease and NAFLD coexistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.