Evidence map›Paper›PMID 40598583›Full record

ArticleEpigenetics & chromatin2025

Detecting Protein-DNA binding in single molecules using antibody guided methylation.

Apoorva Thatavarty, Naor Sagy, Michael R Erdos, Isac Lee, Jared T Simpson, Winston Timp, Francis S Collins, Daniel Z Bar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics & chromatin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Apoorva ThatavartyDepartment of Pediatrics - Division of Infectious Disease, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Naor SagyDepartment of Oral Biology, Goldschleger School of Dental Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Michael R ErdosCenter for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA.
Isac LeeDepartment of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD, USA.
Jared T SimpsonOntario Institute for Cancer Research, Toronto, ON, Canada.
Winston TimpDepartment of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD, USA.
Francis S CollinsCenter for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA.
Daniel Z BarDepartment of Oral Biology, Goldschleger School of Dental Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. dbar@tauex.tau.ac.il.

Funding

Hematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3M
Nanopore based profiling of epigenetic stateR01HG009190 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI TIMP, WINSTON GEORGE · 2017 to 2024
$4.8M
Israel Science Foundation 654/20NHGRI NIH HHS R01 HG009190NIDDK NIH HHS T32 DK060445NIH HHS HG-200305
6 · The paper itself

Abstract

Characterization of DNA binding sites for specific proteins is of fundamental importance in molecular biology. It is commonly addressed experimentally by chromatin immunoprecipitation and sequencing (ChIP-seq) of bulk samples (10

Indexed as

DNADNA-Binding ProteinsDNA MethylationAntibodiesBinding SitesHumansProtein BindingAntibodiesDNADNA-Binding Proteins

Identifiers

PMID40598583
PMCPMC12210839

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.