ReviewBiology of sex differences2025
Interindividual and sex differences in resilience and vulnerability to post-traumatic stress disorder (PTSD): insights from animal models.
Review in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies.Military Medical Research · 2026Review
- Continuous OFT-Based Behavioral Phenotyping Reveals Neural Stem Cell-Associated Shifts in Depression-like Mice.Brain sciences · 2026Article
- Epigenetic Control of Stress-Induced Depression: Emerging Roles of HDAC3 and HDAC6.International journal of molecular sciences · 2026Review
- Phenotype-Specific Transcriptomic Responses to Glucocorticoid Signaling in the Prefrontal Cortex and Dorsal Raphe Nucleus Following Chronic Social Stress.International journal of molecular sciences · 2026Article
- Hypothesis on PTSD Pathophysiology: Role of CRH, Noradrenaline, and Glucocorticoid Receptors in an Amygdala-Centered Closed-Loop System.International journal of molecular sciences · 2026Article
- Quetiapine ameliorates sensorimotor gating, recognition memory, and neuroendocrine plasticity in chronic stress-induced female rats.Metabolic brain disease · 2026Article
- Longitudinal shifts in avoidance-based phenotypes in a predator odor conditioned place aversion model of posttraumatic stress disorder.Frontiers in behavioral neuroscience · 2026Article
- Sub-chronic stress exerts partially distinct behavioral and epigenetic effects in male and female mice.Frontiers in behavioral neuroscience · 2025Article
- Proteomic insights into extinction memory deficits in stress-susceptible female rats.Frontiers in behavioral neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Stress triggers many responses including behavioral strategies to cope with the environment and to maintain homeostasis. Notably, the experience of stressful events is highly subjective. In fact, in susceptible individuals, primary adaptation responses can fail leading to maladaptive mechanisms and to the subsequent development of stress-related disorders (e.g., post-traumatic stress disorder; PTSD). However, the mechanisms underlying interindividual variability in stress adaptation are still to be elucidated. Animal models are widely recognized as essential scientific tools to understand the neurobiological underpinnings of stress susceptibility/resilience, and as tools to identify novel and personalized interventions to treat (and prevent) such disorders in humans. Experimental models have however several limitations, as validity criteria can be very problematic when modeling psychiatric disorders. Also, while sex dimorphism crucially contributes to the risk for stress-related diseases, several frequently used models overlooked sex differences in the interindividual variability in response to stress. In this review, we describe the interindividual and sex differences in susceptibility and resilience in stress-related disorders, with a particular focus on PTSD. Further, we examine aspects of animal models of PTSD that can be improved to obtain higher translational value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.