Evidence map›Paper›PMID 40598663›Full record

ArticleBiology of sex differences2025

Associations of street-view greenspace exposure with cardiovascular health (Life's Essential 8) among women in midlife.

Sheryl L Rifas-Shiman, Li Yi, Izzuddin M Aris, Pi-I Debby Lin, Marie-France Hivert, Jorge E Chavarro, Esra Suel, Peter James, Emily Oken

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Article in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA. sheryl_rifas@hphci.harvard.edu.
Li YiDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Izzuddin M ArisDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Pi-I Debby LinDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Jorge E ChavarroDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Esra SuelCentre for Advanced Spatial Analysis, University College London, London, UK.
Peter JamesDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
The roles of NK3RMnPO and KNDy neurons in vasomotor symptoms, sleep, and cognition in E2 depleted mice.U54AG062322 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HADINE JOFFE · 2020 to 2026
$13.7M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular HealthR01HL150119 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAMES, PETER · 2020 to 2024
$3.9M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
NHLBI NIH HHS R01 HL150119NIA NIH HHS U54 AG062322NICHD NIH HHS R01 HD034568NIEHS NIH HHS R24 ES030894NIH HHS UH3 OD023286U.S. National Institutes of Health R24ES030894, R01HL150119, R01HD034568, UH3OD023286
6 · The paper itself

Abstract

backgroundMany women experience suboptimal cardiovascular health (CVH) during midlife. Greenspace exposure has been inversely associated with cardiovascular disease because it may reduce harmful environmental exposures and promote healthy behaviors. Most prior studies used satellite-based rather than ground-level exposures and did not examine overall CVH.

methodsWe performed a longitudinal analysis of women in the Project Viva cohort based in Eastern Massachusetts. We applied deep learning algorithms to Google Street View images to derive metrics of visible trees, grass, and other greenspace within 500 m of participant's residential addresses in 2012-2016 (mean age 46 years). About five years later (mean age 51 years), participants completed questionnaires and research measurements including blood collection. We calculated CVH scores using Life's Essential 8 (LE8) construct (0-100 points, higher = better), which includes four behavioral (diet, physical activity, sleep, and avoidance of smoking) and four biomedical measures (body mass index, blood pressure, blood lipids, and blood glucose). We used linear regression models adjusted for age and both individual- and neighborhood-level socioeconomic status.

resultsAmong 767 participants, 68% were non-Hispanic White, and 74% were college graduates. Mean (SD) CVH score was 72 (13) points. When including three greenspace components in the same model, higher % trees (per SD) was associated with higher overall CVH score (β = 2.4; 95% CI: 1.3, 3.5), as well as higher behavioral (β = 2.8; 95% CI: 1.4, 4.3) and biomedical (β = 2.8; 95% CI: 1.0, 4.7) sub-scores. Additionally, % other greenspace (per SD) was associated with better biomedical CVH scores (β = 2.2; 95% CI: 0.4, 3.9), whereas associations for % grass were non-significant. Higher % trees (per SD) was associated with higher scores for most individual CVH components, including diet (β = 2.1 points; 95% CI: 0.7, 3.4), physical activity (β = 4.0; 95% CI: 1.2, 6.9), sleep (β = 2.6; 95% CI: 0.9, 4.4), BMI (β = 5.8; 95% CI: 2.8, 8.8), and blood glucose (β = 2.2; 95% CI: 0.3, 4.2).

conclusionsGreater street-view greenspace exposure, especially visible trees in streetscapes, was associated with better CVH among midlife women. Increasing trees in neighborhoods may be a valuable public health strategy to improve multiple metrics of cardiovascular health.

Indexed as

Cardiovascular DiseasesNeighborhood CharacteristicsAdultExerciseFemaleHumansLongitudinal StudiesMassachusettsMiddle AgedCardiovascular healthDeep learning algorithmsFemalesGreen spaceLife’s essential 8MidlifeStreet-view imagery

Identifiers

PMID40598663
PMCPMC12219997

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.