ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025
[Differential Characteristics of Human Airway Organoids at Different Stages of Differentiation After Respiratory Syncytial Virus Infection].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
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Abstract
Objective: To investigate the differences in pathological changes and immune responses of human airway organoids at different stages of differentiation following respiratory syncytial virus (RSV) infection. Methods: Models of human fetal lung organoids (FLO) and induced airway organoids (iAO) were established to simulate immature and mature airway epithelium. Immunofluorescence staining, electron microscopy, and quantitative polymerase chain reaction (Q-PCR) were used to confirm the successful construction of the lung organoid models. Human lung organoids were infected with RSV, and samples were collected at 6 and 48 hours post-infection. The immune characteristics of immature and mature RSV-infected organoids were assessed using immunofluorescence staining, droplet digital PCR (DDPCR), and Q-PCR. Results: We successfully generated FLO expressing both the progenitor markers sex determining region Y-box transcription factor 2 ( Conclusion: The expression of RSV infection receptor proteins increases with airway maturation, and mature airway epithelial cells exhibit a stronger immune response than immature ones do, effectively inhibiting RSV replication.
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