Evidence map›Paper›PMID 40599331›Full record

ArticleBioinformatics advances2025

Pharmacological assessment of

Victor Omoboyede, Nwachukwu Christiana Okonkwo, Jimoh Olayemi Balogun, Onyekachi Victor Onyedikachi, Rita Ononiwu, Daniel Okpaise, Sarah Olanrewaju Oladejo, Christopher Busayo Olowosoke, Haruna Isiyaku Umar, Prosper Obed Chukwuemeka

Abstract read
In one paragraph

Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victor OmoboyedeDepartment of Biochemistry, School of Life Sciences (SLS), Federal University of Technology Akure, Akure, P.M.B 704, Nigeria.ORCID https://orcid.org/0000-0003-1973-0882
Nwachukwu Christiana OkonkwoDepartment of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Anambra State, P.M.B 5025, Nigeria.ORCID https://orcid.org/0009-0006-2251-6341
Jimoh Olayemi BalogunDepartment of Microbiology, Lead City University, Ibadan, Oyo State, 200255, Nigeria.ORCID https://orcid.org/0009-0004-6142-3864
Onyekachi Victor OnyedikachiDepartment of Microbiology, College of Natural Sciences, Michael Okpara University of Agriculture Umudike, Umuahia, Abia State, P.M.B 7267, Nigeria.ORCID https://orcid.org/0000-0003-4091-3771
Rita OnoniwuDepartment of Chemical Sciences, Bells University of Technology, Ota, Ogun State, P.M.B 1015, Nigeria.ORCID https://orcid.org/0009-0007-4046-0115
Daniel OkpaiseDepartment of Virology, College of Medicine, University of Ibadan, Ibadan, P.M.B 3017, Nigeria.ORCID https://orcid.org/0009-0000-4982-4332
Sarah Olanrewaju OladejoDepartment of Microbiology, Lagos State University, Ojo (Main campus), Lagos State, P.M.B. 0001, Nigeria.ORCID https://orcid.org/0000-0003-3320-7422
Christopher Busayo OlowosokeComputer-Aided Therapeutic Discovery and Design Group, Akure, Ondo State, P.M.B. 704, Nigeria.ORCID https://orcid.org/0000-0002-4315-3184
Haruna Isiyaku UmarDepartment of Biochemistry, School of Life Sciences (SLS), Federal University of Technology Akure, Akure, P.M.B 704, Nigeria.ORCID https://orcid.org/0000-0001-9427-9804
Prosper Obed ChukwuemekaComputer-Aided Therapeutic Discovery and Design Group, Akure, Ondo State, P.M.B. 704, Nigeria.ORCID https://orcid.org/0000-0001-8381-2802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: Cervical cancer remains a leading cause of gynecological mortality, with existing treatments often limited by resistance and suboptimal efficacy. While Results: From 158 bioactive compounds with favorable pharmacokinetic and drug-likeness properties, we predicted gene targets and intersected them with 1779 differentially expressed genes identified from bulk RNA-sequencing of 304 cervical cancer tumors and 47 normal cervical tissues. This yielded 43 Availability and implementation: The data supporting the findings of this study, including bulk RNA-seq gene expression data, survival, and phenotype data, are available through the TCGA database. These data can be accessed via the Xenabrowser platform (https://xenabrowser.net) using the reference identifier [TCGA Cervical Cancer (CESC)]. Corresponding healthy cervical tissue RNA-seq data, are available through the Genotype-Tissue Expression (GTEx) project (https://www.gtexportal.org/home/). The codes used for differential gene expression (DGE) analysis, pathway enrichment, and survival analysis, as well as scripts for generating volcano plots (DGE analysis), Kaplan-Meier survival plots, and boxplots (gene expression), and machine learning implementations are available on GitHub (https://github.com/Ponaskillzyy/Coffea_arabica_Potential_in_Cervical_Cancer).

Identifiers

PMID40599331
PMCPMC12212767

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.