ArticleFrontiers in aging neuroscience2025
Brain microvascular calcification is increased in human donors with dementia compared to elderly controls: a pilot study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Introduction: Intracranial vascular calcification has been observed in the setting of both Alzheimer's disease (AD) and vascular dementia. Increased calcification in intracranial and extracranial arteries is associated with an increased risk of dementia; however, less is known about the prevalence and implications of microvascular calcification in AD and related dementias. In this study, we compared microvascular calcification in AD-relevant brain regions between human donors with vs. without dementia and/or late-onset AD diagnoses. Methods: Brain tissue was sampled bilaterally from basal ganglia, hippocampus, posterior cingulate cortex, substantia nigra, and subventricular zone, along with bilateral carotid arteries in a cohort of human donor cadavers with and without dementia at death ( Results: Our findings indicate higher odds of dementia per one quartile increase in microvascular calcification volume in the hippocampus [OR 9.601 (CI 2.518, 86.803), Discussion: Our findings indicate that microvascular calcification impacts brain regions relevant to morphologic changes (hippocampus) and hypoperfusion (posterior cingulate cortex) in AD. Our study expands on a recent report of increased brain calcification in the setting of AD, suggesting that microvascular calcification carries pathophysiological significance in the development and/or progression of AD and related dementias.
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