Evidence mapPaperPMID 40599396Full record

ReviewInternational journal of nanomedicine2025

How Effective are Key Phytocompound Carrying Polysaccharide Nanocarriers as Anti-Breast Cancer Therapy? A Comprehensive Review of the Literature.

Deena Elsori, Pratibha Pandey, Safia Obaidur Rab, Ahmed M Alharbi, Samir Sahoo, Shivam Pandey, Manish Srivastava, Sorabh Lakhanpal, Mohd Saeed, Fahad Khan

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deena ElsoriFaculty of Resilience, Rabdan Academy, Abu Dhabi, United Arab Emirates.
Pratibha PandeyResearch and Innovation Cell, Rayat Bahra University, Mohali-140301, Punjab, India.
Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Ahmed M AlharbiDepartment of Medical Laboratory Science, College of Applied Medical Sciences, University of Ha'il, Hail, Saudi Arabia.
Samir SahooDepartment of General Medicine, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India.
Shivam PandeySchool of Applied and Life Sciences, Uttaranchal University, Dehradun, India.
Manish SrivastavaDepartment of Endocrinology, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, India.
Sorabh LakhanpalSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Mohd SaeedDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.ORCID 0000-0003-3443-386X
Fahad KhanCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.ORCID 0000-0003-3449-7978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer continues to be one of the most perilous diseases globally due to the challenges in identifying cost-effective and targeted targets for effective treatment strategies. In response to these unmet demands, much research has focused on investigating the anti-breast cancer properties of natural compounds due to their multi-target modes of action and favorable safety profiles. Numerous extracts of medicinal plants, essential oils, and natural bioactive substances have exhibited anticancer properties in preclinical breast cancer models. Nonetheless, the clinical utilization of therapies based on natural chemicals is constrained by challenges such as inadequate solubility and permeability. Innovative drug delivery systems utilizing nanoparticles are currently being investigated as adaptable solutions to overcome these limitations. Polysaccharide-based nanoparticles exhibit promising biodegradability and biocompatibility, making them suitable for targeted drug delivery systems among the diverse nanocarrier types. Many polysaccharide nanocarriers, including chitosan, hyaluronic acid, cellulose, starch, and complex polysaccharides, have been shown to enhance the bioavailability and therapeutic effectiveness of phytocompounds. This review examines the anticancer properties of phytocompounds and polysaccharide nanocarriers in breast cancer before focusing on the use of polysaccharide-based nanocarriers to deliver phytocompounds for the treatment of breast cancer.

Indexed as

Antineoplastic Agents, PhytogenicBreast NeoplasmsDrug CarriersNanoparticle Drug Delivery SystemNanoparticlesPhytochemicalsPolysaccharidesAnimalsAntineoplastic AgentsDrug Delivery SystemsFemaleHumansAntineoplastic AgentsAntineoplastic Agents, PhytogenicDrug CarriersNanoparticle Drug Delivery SystemPhytochemicalsPolysaccharidesbreast cancerdrug deliverynanocarriersphytocompoundspolysaccharide

Identifiers

PMID40599396
PMCPMC12212098

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.