Evidence map›Paper›PMID 40599401›Full record

ReviewInternational journal of nanomedicine2025

Advancements in Nano-Delivery Systems for Photodynamic and Photothermal Therapy to Induce Immunogenic Cell Death in Tumor Immunotherapy.

Rui Zhao, Shuai Li, Jingyuan Zhao, Chenhui Yao

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Organic Semiconducting Polymers for Cancer Sonodynamic Immunotherapy.Polymer science & technology (Washington, D.C.) · 2026
    Review
  8. Article
  9. Review
  10. Hollow CuInternational journal of nanomedicine · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rui Zhao *Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.ORCID 0000-0002-4820-530X
Shuai Li *Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.ORCID 0000-0002-3492-7176
Jingyuan ZhaoClinical Laboratory Center, Central Hospital of Dalian University of Technology, Dalian, People's Republic of China.
Chenhui YaoDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inducing immunogenic cell death (ICD) can tackle the issue of low immune response levels in tumor immunotherapy. Photodynamic therapy (PDT) uses photosensitizers to generate reactive oxygen species that kill tumor cells, while photothermal therapy (PTT) directly uses heat from photothermal converters to destroy tumor cells. However, these single treatments have their limitations. The development of optical therapy nanodelivery systems, along with the combination of PTT/PDT with chemotherapy and immunotherapy, offers new strategies for tumor immunotherapy. This article explores the application of PDT and PTT mediated by nanodelivery systems in promoting immunogenic cell death in tumor cells. This article explores nano-delivery systems that precisely release photosensitizers to boost efficacy and reduce toxicity. It also discusses their potential for combination therapy through co-delivery, utilizing multimodal strategies to enhance both phototherapy and chemotherapy, thus improving anticancer effectiveness.

Indexed as

Drug Delivery SystemsImmunogenic Cell DeathImmunotherapyNanoparticle Drug Delivery SystemNeoplasmsPhotochemotherapyPhotothermal TherapyAnimalsCombined Modality TherapyHumansNanomedicineNanoparticlesPhotosensitizing AgentsReactive Oxygen SpeciesNanoparticle Drug Delivery SystemPhotosensitizing AgentsReactive Oxygen Speciesdelivery systemimmunogenic cell deathnanophotodynamic therapyphotothermal therapy

Identifiers

PMID40599401
PMCPMC12209404

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.