Evidence map›Paper›PMID 40599431›Full record

ArticleComprehensive psychoneuroendocrinology2025

Default mode network static-dynamic functional signatures in first-episode drug-naive major depressive disorder.

Xiaoyun Liu, Kaimo Ding, Fan Li, Xiaotong Zhang, Zhenghua Hou, Yingying Yin, Youyong Kong, Yonggui Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comprehensive psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoyun LiuDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China.
Kaimo DingZhenjiang Mental Health Center, Jiangsu Province, Zhenjiang, China.
Fan LiLab of Image Science and Technology, School of Computer Science and Engineering, Key Laboratory of Computer Network and Information Integration, Ministry of Education, Southeast University, Nanjing, China.
Xiaotong ZhangLab of Image Science and Technology, School of Computer Science and Engineering, Key Laboratory of Computer Network and Information Integration, Ministry of Education, Southeast University, Nanjing, China.
Zhenghua HouDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China.
Yingying YinDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China.
Youyong KongLab of Image Science and Technology, School of Computer Science and Engineering, Key Laboratory of Computer Network and Information Integration, Ministry of Education, Southeast University, Nanjing, China.
Yonggui YuanDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

•In this study, we investigated the altered static and dynamic function of DMN in first-episode drug-naive MDD (FEDN) for the first time.•We found that the TV of dMPFC in FEDN was significantly increased, while the sFC within DMN were decreased both in FEND and rMDD.•In addition, we found that the TV of dMPFC in FEDN was significantly positively associated with HAMD-24 scores.•These findings provide evidence for disorder-specific abnormal functional patterns and offered a new perspective for future research on fluctuating dynamic neural communication in FEDN.

Identifiers

PMID40599431
PMCPMC12209975

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.