Evidence map›Paper›PMID 40599681›Full record

ArticleFrontiers in allergy2025

Effects of

Muzhda Ghanizada, Sofia Malm Tillgren, Louis Praeger-Jahnsen, Nihaya Mahmoud Said, Sisse Ditlev, Helle Frost Andreassen, Nanna Dyhre-Petersen, Samuel Cerps, Asger Sverrild, Celeste Porsbjerg and 3 more

Abstract read
In one paragraph

Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Muzhda Ghanizada *Respiratory Research Unit, Department of Respiratory and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark.
Sofia Malm Tillgren *Unit of Respiratory Immunopharmacology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Louis Praeger-JahnsenCopenhagen Centre for Translational Research, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Nihaya Mahmoud SaidRespiratory Research Unit, Department of Respiratory and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark.
Sisse DitlevCopenhagen Centre for Translational Research, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Helle Frost AndreassenRespiratory Research Unit, Department of Respiratory and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark.
Nanna Dyhre-PetersenRespiratory Research Unit, Department of Respiratory and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark.
Samuel CerpsUnit of Respiratory Immunopharmacology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Asger SverrildRespiratory Research Unit, Department of Respiratory and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark.
Celeste PorsbjergRespiratory Research Unit, Department of Respiratory and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark.
Lena UllerUnit of Respiratory Immunopharmacology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Therese LapperreRespiratory Research Unit, Department of Respiratory and Infectious Diseases, Bispebjerg Hospital, Copenhagen, Denmark.
Mandy MenzelUnit of Respiratory Immunopharmacology, Department of Experimental Medical Science, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Azithromycin (AZM) effectively reduces asthma exacerbations and enhances bronchial epithelial cell (BEC) antiviral immunity Objectives: To explore bronchial epithelial antiviral properties in response to Methods: In this cross-sectional study, we have collected BECs from patients with moderate-to-severe asthma ( Results: AZM significantly enhanced IFN-β and IFN-λ protein release in response to RV infection both in eosinophilic and in non-eosinophilic asthma as well as in non-atopic asthma. A less pronounced IFN-β and IFN-λ protein release was also observed in the atopic group. AZM's interferon-inducing effect was, however, largely similar regardless of blood eosinophil count and atopy status. Additionally, AZM prompted the release of TSLP and IL-6 in the non-eosinophilic group only. Conclusions: Our data suggest that

Indexed as

antiviral immunityasthma exacerbationatopyazithromycin (AZM)bronchial epithelial cellrhinovirus

Identifiers

PMID40599681
PMCPMC12209221

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.