Evidence map›Paper›PMID 40599698›Full record

ArticleeNeurologicalSci2025

Antecedent sedative use is independently associated with stroke occurrence among west Africans: Evidence from the SIREN case-control study.

Ezinne O Uvere, Joshua Akinyemi, Fred S Sarfo, Adekunle Fakunle, Akinkunmi Paul Okekunle, Onoja Akpa, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe and 31 more

Abstract read
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In one paragraph

Article in eNeurologicalSci, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Ezinne O UvereDepartment of Medicine, University of Ibadan, Nigeria.
Joshua AkinyemiDepartment of Epidemiology and Medical Statistics, University of Ibadan, Nigeria.
Fred S SarfoDepartment of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Adekunle FakunleDepartment of Public Health, Osun State University, Osogbo, Nigeria.
Akinkunmi Paul OkekunleDepartment of Epidemiology and Medical Statistics, University of Ibadan, Nigeria.
Onoja AkpaDepartment of Epidemiology and Medical Statistics, University of Ibadan, Nigeria.
Albert AkpaluDepartment of Medicine, University of Ghana Medical School, Accra, Ghana.
Kolawole WahabDepartment of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Reginald ObiakoDepartment of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Morenikeji KomolafeDepartment of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.
Lukman OwolabiDepartment of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
Godwin O OsaigbovoJos University Teaching Hospital Jos, Nigeria.
Godwin OgboleDepartment of Radiology, University of Ibadan, Nigeria.
Hemant K TiwariUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Carolyn JenkinsMedical University of South Carolina, USA.
Samuel OlowookereFederal Medical Centre, Abeokuta, Nigeria.
Oyedunni ArulogunDepartment of Health Promotion and Education, University of Ibadan, Nigeria.
Josephine AkpaluDepartment of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Osahon J AsowataDepartment of Epidemiology and Medical Statistics, University of Ibadan, Nigeria.
Philip IbinaiyeDepartment of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
Cynthia AkisanyaFederal Medical Centre, Abeokuta, Nigeria.
Olalekan I OyinloyeDepartment of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.
Lambert AppiahDepartment of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Atinuke M AgunloyeDepartment of Medicine, University of Ibadan, Nigeria.
Abiodun M AdeoyeDepartment of Medicine, University of Ibadan, Nigeria.
Joseph YariaDepartment of Medicine, University College Hospital, Ibadan, Nigeria.
Daniel T LacklandMedical University of South Carolina, USA.
Donna ArnettCollege of Public Health, University of Kentucky, KY, USA.
Ruth Y LaryeaDepartment of Medicine, University of Ghana Medical School, Accra, Ghana.
Benedict Calys-TagoeCollege of Public Health, University of Kentucky, KY, USA.
Okechukwu S OgahDepartment of Medicine, University of Ibadan, Nigeria.
Mayowa OgunronbiFederal Medical Centre, Abeokuta, Nigeria.
Suleiman Y IsahDepartment of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
Hamisu A DambattaDepartment of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
Raelle TaggeWeill Institute for Neurosciences, School of Medicine, University of California San Francisco, USA.
Olayemi BalogunDepartment of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Obiageli U Agbogu-IkeDepartment of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Rufus AkinyemiDepartment of Medicine, University of Ibadan, Nigeria.
Bruce OvbiageleWeill Institute for Neurosciences, School of Medicine, University of California San Francisco, USA.
Mayowa OwolabiDepartment of Medicine, University of Ibadan, Nigeria.
SIREN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Several factors have been independently associated with stroke occurrence globally. However, the association between sedative use and stroke risk is yet to be established in West Africa. Objective: To assess the association between sedatives and stroke among West Africans. Methods: Adults aged ≥18 years with confirmed stroke as well as age- and sex-matched controls were enrolled into the Stroke Investigative Research and Education Network (SIREN) study. Sedative use was determined by retrospective assessment on the use of any type of sedative in the preceding year while stroke was confirmed with brain scan and clinical features. Univariate and multivariate analyses, using logistic regressions, were performed to establish associations between sedative use and stroke while adjusting for other stroke risk factors. Results: A total of 7104 subjects (3553 stroke cases and 3551 stroke-free controls participated in this study. The mean age was 60.9 ± 0.78 among cases and 59.8 ± 11.44 years among controls ( Conclusion: Sedative use was independently associated with stroke risk among adults in West Africa. Its use requires further exploration and prospective study to address the emerging association with stroke occurrence.

Indexed as

Risk factorsSedative useStrokeWest Africa

Identifiers

PMID40599698
PMCPMC12209909

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.