Evidence map›Paper›PMID 40599718›Full record

ArticleMolecular and clinical oncology2025

Nuclear factor IA-mediated transcriptional regulation of crystallin αB inhibits hepatocellular carcinoma progression.

Yun Jin, Pingping Hu, Yihe Dai, Wenchao Gu, Jiang Han, Haihan Song

Abstract read
In one paragraph

Article in Molecular and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yun JinDepartment of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China.
Pingping HuDepartment of Hepatobiliary Surgery, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, P.R. China.
Yihe DaiDepartment of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China.
Wenchao GuDepartment of Pulmonary and Critical Care Medicine, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China.
Jiang HanDepartment of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China.
Haihan SongCentral Laboratory, Shanghai Key Laboratory of Pathogenic Fungi Medical Testing, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly invasive malignant tumor with limited therapeutic options. In the present study, bioinformatics analysis, including differential expression analysis, functional enrichment, protein-protein interaction network construction, survival analysis and risk model evaluation, identified CRYAB as a central prognostic gene in HCC. Additionally, motif analysis using JASPAR revealed nuclear factor IA (NFIA), as a potential transcriptional regulator of CRYAB. Further

Indexed as

crystallin αBhepatocellular carcinomain vitro evaluationnuclear factor IAtranscriptional regulation

Identifiers

PMID40599718
PMCPMC12210110

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.