ArticleJournal of physical therapy science2025
Effect of hypoxia-inducible factor 1 alpha inhibitor on immobilization-induced muscle fibrosis related to muscle contracture.
Article in Journal of physical therapy science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
[Purpose] To test the effect of the hypoxia-inducible factor 1-alpha (HIF-1α) inhibitor, YC-1, on the upregulation of HIF-1α that leads to immobilization-induced muscle fibrosis underlying muscle contracture. [Materials and Methods] Rats were divided into control, immobilization (immobilization only), and YC-1 (immobilization and YC-1 injection) groups. The soleus muscles were the specimens. [Results] The HIF-1α protein expression in the control, immobilization, and YC-1 groups was 0.26 ± 0.11, 0.94 ± 0.28, and 0.66 ± 0.15, respectively. The expression of HIF-1α protein in the immobilization and YC-1 groups was significantly higher than in the control group and it was lower in the YC-1 group than in the immobilization group. There were strong positive correlations between HIF-1α protein expression and transforming growth factor (TGF)-β1 mRNA expression, TGF-β1 and α-smooth muscle actin (SMA) mRNA expressions, and between α-SMA mRNA expression and hydroxyproline content. A strong negative correlation was found between hydroxyproline content and range of motion on dorsiflexion at four-weeks. [Conclusion] Inhibition of HIF-1α may contribute to suppressing the overexpression of fibrosis-related molecules triggered by upregulation of HIF-1α, which may mitigate immobilization-induced muscle fibrosis related to muscle contracture.
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