ArticleJournal of pediatric gastroenterology and nutrition2025
Mast cells infiltrates are common in eosinophilic esophagitis and still elevated in histological remission: A digital evaluation in children.
Article in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Relationship Between Eosinophilic Esophagitis and Laryngeal Manifestations: Pathophysiology, Clinical Overlap, and Diagnostic Challenges.Journal of clinical medicine · 2026Review
- Three-dimensional modeling of sensory nerve architecture and eosinophil and mast cell interactions in eosinophilic gastrointestinal disease.Journal of leukocyte biology · 2026Article
- Eosinophilic Esophagitis as a Complex Th2 Inflammatory Disease: Results of a Prospective Long-Term Study in Children.Digestive diseases (Basel, Switzerland) · 2026Article
- Mast cells infiltrates are common in eosinophilic esophagitis and still elevated in histological remission: A digital evaluation in children.Journal of pediatric gastroenterology and nutrition · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesEosinophilic esophagitis (EoE) is a type 2 inflammatory chronic allergic disease with several additional immune cell subsets being involved. The aim of this study was to assess the identification and quantification of mast cells (MC) infiltrates using an objective and examiner independent analysis via digital image analysis of digitized histochemically stained biopsies.
methodsBiopsies were taken from the esophagus of 24 children and adolescents diagnosed with EoE and stained for MC and eosinophilic granulocytes using anti-CD117 and Congo red, respectively. Samples were digitized, eosinophilic granulocytes and MCs were quantified using the MIKAIA® image analysis software.
resultsAt diagnosis MC infiltrations were regularly observed in active disease. MC numbers were 160 (cells/mm
conclusionsMast cells are involved in EoE and persist after achieving histological remission. Both CD117 + MC and eosinophilic granulocytes can be quantified using MIKAIA® as a tool for objectifying the histological diagnosis of EoE.
trial registrationIdentification number: DRKS-ID 00014688; https://drks.de/search/de/trial/DRKS00014688.
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