Evidence map›Paper›PMID 40600428›Full record

ArticleJournal of medical virology2025

Oncogenic Potential of Epstein-Barr Virus in NK and NKT Cells Contribute to the Rapid Deterioration of Hemophagocytic Lymphohistiocytosis.

Tingting Cui, Mingzhu Huang, Yuan Wang, Zhengfang Lin, Xiaoling Su, Weidong Li, Qi Luo, Kaiyi Li, Chunyan Wang, Runhui Zheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tingting CuiState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Mingzhu HuangGuangdong Provincial Second Hospital of Traditional Chinese Medicine, Guangzhou, China.
Yuan WangKey Laboratory of Emergency and Trauma of Ministry of Education, Engineering Research Center for Hainan Biological Sample Resources of Major Diseases, Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, The First Affiliated Hospital of Hainan Medical University, Hainan, China.
Zhengfang LinDepartment of Clinical Laboratory, Dongguan Maternal and Child Health Care Hospital, Dongguan, China.
Xiaoling SuState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Weidong LiState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Qi LuoState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Kaiyi LiState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Chunyan WangDepartment of Hematology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Runhui ZhengDepartment of Hematology, the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhongfang WangState Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

Funding

This study was supported National Key Technologies Research and Development Program, S&T Program of Guangzhou Laboratory, Major Project of Guangzhou National Laboratory, National Natural Science Foundation of China, and R&D Program of Guangzhou National Laboratory.
6 · The paper itself

Abstract

The rapid deterioration and fatal outcomes in Epstein-Barr virus (EBV)-related hemophagocytic lymphohistiocytosis (HLH) remain poorly understood. This study aimed to elucidate the key factors contributing to the progression of EBV-HLH by comparing EBV cellular tropism and host immune responses between survivors and deceased patients. Compared to healthy individuals, acute HLH patients exhibited impaired natural killer (NK) cell activity, which improved during the recovery phase. However, deceased patients demonstrated heightened NK cell activity and increased EBV loads during the deterioration phase. Additionally, deceased patients had elevated EBV-specific T cell responses without cytokine storm, suggesting other factors beyond host immunity contribute to HLH deterioration. Notably, in deceased cases, EBV infection spread to NK and NKT cells with a highly proliferative profile, whereas it was limited to B cells in survivors. Furthermore, EBV-infected NK and NKT cells displayed a higher percentage of copy number variations and significant enrichment in canonical cancer pathways compared to noninfected cells, indicating their oncogenic potential and possible contribution to HLH deterioration. These findings provide insights into the pathogenesis of EBV-HLH and may guide the development of targeted therapeutic strategies.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanKiller Cells, NaturalLymphohistiocytosis, HemophagocyticNatural Killer T-CellsAdolescentAdultAgedB-LymphocytesChildChild, PreschoolFemaleHumansMaleMiddle AgedViral LoadEBV‐HLHEBV‐infected NK/NKTEBV oncogenicityhost immunity

Identifiers

PMID40600428
PMCPMC12216793

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.