ArticlePsychiatry and clinical neurosciences2025
Cognitive subtypes in youth at clinical high risk for psychosis.
Article in Psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Temporal integration window of sensory processing as a neuropsychological marker for clinical high risk of psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Multi-domain destructuring in the early phases of psychosis: a multicentric phenomenological and psychometric case-control study.Frontiers in behavioral neuroscience · 2025Article
Corrections and comments
- Update of
Authors and funding
14 authors.
Funding
Abstract
aimsThis study aimed to identify and characterize cognitive subtypes among youth at clinical high risk (CHR) for psychosis.
methodsWe conducted a cluster analysis on cognitive measures in a large sample of CHR patients (CHR; n = 764) and healthy controls (HCs; n = 280) from NAPLS-2 (North American Prodrome Longitudinal Study 2). These findings were independently validated using a comparably large sample from NAPLS-3 (n = 628 CHR, 84 HCs). Statistical approaches were employed to compare cognitive, clinical, and functional trajectories at baseline and during 24 months of follow-up, with further analysis of conversion status within these clusters.
resultsTwo cognitive clusters, "impaired" and "intact," were identified in the CHR group. Baseline differences in verbal abilities and attention and working memory domains distinguished the cognitively intact cluster from HCs. Longitudinally, the impaired group displayed a 'floor' effect, with no noticeable deterioration, but showed a "catch-up" trajectory in attention and working memory. This group had a higher conversion rate and more cases diagnosed with psychotic disorders than the intact group. In the intact group, converters exhibited a decline in attention and functioning. Most cognitive trajectories showed a positive relationship with functional outcomes.
conclusionsThe study provides evidence for distinct cognitive subtypes in CHR, independent of conversion status. Early evaluation across cognitive domains is crucial for identifying trajectories to tailor interventions that aim to enhance outcomes for individuals at CHR for psychosis. Future research should focus on longer follow-up trajectories targeting attention and working memory and explore related intervention strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.