ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Superficial Peritoneal Endometriosis Beyond Surgical Diagnosis: A Narrative Review of Emerging Functional and Molecular Perspectives.Medicina (Kaunas, Lithuania) · 2026Review
- The Therapeutic Role of Dienogest in Endometriosis-Associated Pain: From Basics to Clinics.Biomolecules · 2026Review
- Immune escape in endometriosis: mechanisms, reprogramming strategies, and precision interventions.Reproductive biology and endocrinology : RB&E · 2026Review
- Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways.Current issues in molecular biology · 2026Review
- Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.Nature genetics · 2026Article
- MRGPRX2 as a novel therapeutic target in headache.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Mast cell-expressed Mrgprb2/MRGPRX2 mediates gout pain and inflammation via a neuroimmune axis.JCI insight · 2026Article
- Deciphering immune-inflammatory dysregulation in the endometriotic microenvironment: insights from single-cell omics and artificial intelligence.Frontiers in immunology · 2026Review
- Immune-nutritional interactions in endometriosis: current evidence and future perspectives in disease management.Frontiers in immunology · 2026Review
- The Histamine-Associated Inflammatory Landscape of Endometriosis: Molecular Profiling of HDC, HRH1-HRH4, and Cytokines Across Lesion Subtypes.International journal of molecular sciences · 2025Article
- MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis.International journal of biological sciences · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The studies on how mast cells mediate endometriosis pain are still limited. Mas-related G protein-coupled receptor member X2 (MRGPRX2), a receptor expressed on mast cells, participates in pain, inflammation, and itch. However, it is still unclear whether and how MRGPRX2 mediates endometriosis pain. Here, we found that the knockout of mast cells alleviated endometriosis-induced hyperalgesia. The density of MRGPRX2-positive mast cells was increased in endometriotic lesions. HBD-2 was secreted from endometriotic cells. Upon HBD-2 treatment, a significant increase in histamine release in the culture supernatant of HMC1.1 cells was detected, whereas no change in histamine levels was observed in the supernatant of MRGPRX2 KO cells. An incubation with histamine increased Ca2+ influx in DRG cells in vitro, whereas desloratadine reversed this process. In Mrgprb2-deficient endometriosis model mice, gene ablation effectively alleviated hyperalgesia and reduced the size of endometriotic lesions. Overall, MRGPRX2 mediates cell-induced endometriosis pain through sensory neurons sensitization via the histamine/HRH1/TRPV1 signaling pathway and can serve as a novel therapeutic target for endometriosis pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.