Observational studyClinical cardiology2025
A Rising Crisis: Escalating Burden of Diabetes Mellitus and Hypertension-Related Mortality Trends in the United States, 2000-2023.
Observational study in Clinical cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Ethnic and Gender Disparities in Risk Factors for Prediabetes-A Retrospective Exploratory Analysis in Southern Israel.Journal of clinical medicine · 2026Article
- A Multisite, Randomized Trial Testing a Community-Digital Health Intervention among Black and Latino Adults with Cardiometabolic Conditions: The Roots of Wellness (Raíces del Bienestar) Protocol.medRxiv : the preprint server for health sciences · 2026Article
- Remote Patient Monitoring in Louisiana Medicare Beneficiaries With Diabetes or Hypertension: Retrospective Cohort Study of 2016-2020 Claims Data.Journal of medical Internet research · 2026Article
- Trends and disparities in aortic dissection mortality in the united states: a retrospective analysis.BMC cardiovascular disorders · 2026Article
- Diabetes mellitus in Pakistan: prevalence and preventive management strategies - a comprehensive literature review.Cardiovascular diabetology. Endocrinology reports · 2025Review
- Trends and Disparities in Cancer-Related Mortality Among Adults With Diabetes in the United States: 1999-2019.Endocrinology, diabetes & metabolism · 2025Review
- Editorial: Advances in diabetes and hypertension research.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
introductionDiabetes mellitus and hypertension are major contributors to cardiovascular and renal disease mortality, yet their combined long-term impact on mortality trends in the United States remains underexplored. This study evaluates national trends in DM and hypertension-related mortality from 2000 to 2023, analyzing disparities across sex, age groups, race/ethnicity, urbanization, and geographic regions.
methodsWe analyzed mortality data from the CDC-WONDER database, identifying deaths with DM and hypertension as listed causes among adults aged 25 and older. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated, and temporal trends were assessed using Joinpoint regression to determine annual percentage changes.
resultsA total of 2,742,668 DM and hypertension-related deaths were recorded. The AAMR nearly doubled from 33.7 per 100,000 in 2000 to 66.2 per 100,000 in 2023. A sharp increase was observed from 2018 to 2021 (APC: 16.3 [95% CI: 11.8-19.6]), followed by a decline through 2023. Men had consistently higher mortality rates than females. Mortality rates were highest among older adults (65+ years), Non-Hispanic Black individuals, and nonmetropolitan populations. The South had the highest mortality rates, with Mississippi and the District of Columbia reporting the greatest burden.
conclusionsDM and hypertension-related mortality has significantly increased over the past two decades, with notable demographic and geographic disparities. Public health interventions should prioritize high-risk populations to mitigate mortality trends and improve health equity.
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