ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Characteristics of peripheral blood neutrophil subsets in patients with primary Sjogren's syndrome based on single-cell RNA sequencing.Frontiers in immunology · 2026Article
- Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Synovial chondromatosis (SC) is a rare joint disorder characterized by cartilaginous loose bodies, yet its cellular underpinnings remain incompletely understood. To define the cellular landscape in SC, single-cell RNA sequencing was performed on synovial tissue obtained from both healthy individuals and SC patients. Analysis of this comprehensive dataset revealed significant alterations in the cellular composition and unique transcriptional profiles of key synovial cell populations within SC synovium. Specifically, a marked increase in the proportion of distinct fibroblast subpopulations (F3 and F4) engaged in extracellular matrix (ECM) synthesis and degradation was observed. Concurrently, the macrophage compartment exhibited a notable shift towards M2-like and M4-like phenotypes. Furthermore, an expanded and dynamically transitioning proliferative immune cell (ProIC) population was identified, with distinct C0 and C1 subpopulations showing unique functional characteristics and a differentiation trajectory from C0 to C1. Beyond individual cellular characteristics, interrogation of intercellular communication networks revealed potentially enhanced signaling, particularly between fibroblasts and macrophages mediated by FTL-SCARA5 interactions, and between macrophages and ProICs via CD74-MIF/other CD74 ligand interactions. These findings offer a comprehensive and detailed characterization of the cellular heterogeneity and altered cellular states associated with SC. This detailed cellular atlas provides a crucial foundation for future functional studies aimed at dissecting the precise roles of these observed cellular alterations in SC pathogenesis and exploring potential therapeutic targets.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.