ArticleCVIR endovascular2025
N-Butyl-2-Cyanoacrylate versus Microspheres on Weight Change and Ghrelin Expressions in Swine Bariatric Embolization Model.
Article in CVIR endovascular, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- N-butyl cyanoacrylate glue: the most misunderstood hero in interventional radiology.CVIR endovascular · 2026Article
- Bariatric embolization with N-butyl cyanoacrylate glue: a revival.CVIR endovascular · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundObesity is a global health challenge, leading researchers to explore innovative treatments. Bariatric arterial embolization (BAE), which blocks blood flow to parts of the stomach, shows promise for weight management by affecting hunger hormones like ghrelin. This study aimed to compare the efficacy and safety of n-butyl-2-cyanoacrylate (NBCA) and microspheres in suppressing weight gain and ghrelin expression after BAE in a swine model. MATERIALS AND
methodsFifteen healthy juvenile male farm pigs were randomly allocated into three groups: NBCA embolization (n = 5), microsphere embolization (n = 5), and a control group (n = 5). Embolization targeted the right, left, and short gastric arteries. Weight and fasting plasma ghrelin levels were monitored weekly for 16 weeks. Gastric endoscopy was performed 1 and 4 weeks post-BAE, and each animal's ghrelin-expressing cells in the stomach's fundus, body, and antrum were analyzed.
resultsBy week 16, the NBCA group showed lower weight gain (58.4 ± 17.8%) compared to that in the microsphere (114.0 ± 0.0%; P < .001) and control groups (123.9 ± 18.1%; P < .001). The NBCA group had lower mean ghrelin-expressing cell densities in the gastric fundus (P < .001), body (P = .002), and antrum (P = 0.003) compared to those in the control group, and lower ghrelin-expressing cell densities in the fundus compared to those in the microsphere group (P < .001). Endoscopy at 1-week post-BAE revealed gastric ulcers in 2 pigs in the NBCA group (40%) and all pigs (100%) in the microsphere group, which healed by week 4; no ulcers were found in the control group.
conclusionsIn a swine model of bariatric arterial embolization, NBCA was more effective than microspheres in reducing weight gain and ghrelin expression in the stomach fundus, indicating its potential for managing obesity through BAE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.