Observational studyPloS one2025
Regular physical activity affects brain activities in old individuals: an observational study.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA healthy lifestyle, including regular physical activity, prevents cognitive decline and dementia. Evaluating the influence of regular physical activity on the brain is essential for properly assessing patients' conditions and designing effective therapeutic strategies. We aimed to investigate whether and how electrophysiological brain activity reflects the influence of regular physical activity. METHODS AND
findingsClinical records from 327 patients who visited our outpatient department for dementia were analysed retrospectively. Patients were classified into two groups: 'Active' for those who engaged in regular physical activity and 'Nonactive' for patients who did not. Electrophysiological brain activity was recorded using magnetoencephalography and quantitatively evaluated using three spectral parameters: median frequency, individual alpha frequency, and Shannon's spectral entropy. Cognitive state was assessed using three neuropsychological assessments: the Japanese version of Mini-Mental State Examination (MMSE-J), Frontal Assessment Battery (FAB-J), and Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-J cog). The effects of group ('Active' or 'Nonactive') on the spectral parameters were examined using an analysis of covariance with one of the neuropsychological assessments as a covariate. The size of contribution was quantified in the unit of neuropsychological assessments using a regression model. A main effect of group was observed for all three spectral parameters. The size of contribution was equivalent to approximate changes of 3-11 points in MMSE-J, 3-7 points in FAB-J, and 10-14 points in ADAS-J cog scores. The main limitations of our study are: (1) this study was conducted in a single site; (2) possibility of reverse causality; and (3) some potential confounding factors, such as genetic factors, were not considered.
conclusionsElectrophysiological brain activity reflects the influence of regular physical activity as well as current cognitive states. Such insights are valuable for physicians to design effective therapeutic strategies and provide clinical advice to patients with cognitive impairment and dementia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.