ArticleThe FEBS journal2025
Protein kinase A: a quirky prototype.
Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Protein kinase A (PKA) has served as a prototype for establishing kinase fundamentals, including sequence, structure and catalytic mechanism. However, PKA is quirky in some respects. Its regulatory elements are expressed separately, including type I (RI) regulatory subunits that contain unusual disulphide-linked dimerization and docking domains. Benjamin-Zukerman and colleagues report on the RIβ mutation L50R that disrupts this domain to cause neuronal loss and parkinsonism driven by a PKA mutation. They show that PKA catalytic subunits are released more easily from RIβ subunits containing the L50R mutation, adding depth to our understanding of this neurodevelopmental disorder.
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